Methyl-Donor and Cofactor Nutrient Intakes in the First 2-3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study

Nutrients
Rachael M TaylorAlexis J Hure

Abstract

During the early postnatal period, the impact of nutrition on DNA methylation has not been well studied in humans. The aim was to quantify the relationship between one-carbon metabolism nutrient intake during the first three years of life and global DNA methylation levels at four years. Childhood dietary intake was assessed using infant feeding questionnaires, food frequency questionnaires, 4-day weighed food records and 24-h food records. The dietary records were used to estimate the intake of methionine, folate, vitamins B2, B6 and B12 and choline. The accumulative nutrient intake specific rank from three months to three years of age was used for analysis. Global DNA methylation (%5-methyl cytosines (%5-mC)) was measured in buccal cells at four years of age, using an enzyme-linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships. Data were collected from 73 children recruited from the Women and their Children's Health (WATCH) study. No association was found between one-carbon metabolism nutrient intake and global DNA methylation levels (P> 0.05). Global DNA methylation levels in males were significantly higher than in females (median %5-mC: 1.82 vs. 1.03,...Continue Reading

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Citations

Jul 30, 2020·Medicina·Andrea Maugeri, Martina Barchitta
Dec 13, 2018·European Journal of Clinical Nutrition·Rachael M TaylorAlexis J Hure
Sep 27, 2019·Food Research International·Lívia Beatriz Aparecida Ribeiro SilvaThomas Prates Ong
Jun 28, 2019·Chemical Research in Toxicology·Diana M Paredes-CéspedesAurora E Rojas-García

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Methods Mentioned

BETA
Assay
genotyping

Software Mentioned

Excel
NUTTAB
Xyris
Foodworks
Statistical Analysis System ( SAS )

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