Methyl donor deficiency affects fetal programming of gastric ghrelin cell organization and function in the rat.

The American Journal of Pathology
Carine Bossenmeyer-PourieBernard Beck

Abstract

Methyl donor deficiency (MDD) during pregnancy influences intrauterine development. Ghrelin is expressed in the stomach of fetuses and influences fetal growth, but MDD influence on gastric ghrelin is unknown. We examined the gastric ghrelin system in MDD-induced intrauterine growth retardation. By using specific markers and approaches (such as periodic acid-Schiff, bromodeoxyuridine, homocysteine, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling, immunostaining, reverse transcription-polymerase chain reaction), we studied the gastric oxyntic mucosa cellular organization and ghrelin gene expression in the mucosa in 20-day-old fetuses and weanling pups, and plasma ghrelin concentration in weanling rat pups of dams either normally fed or deprived of choline, folate, vitamin B6, and vitamin B12 during gestation and suckling periods. MDD fetuses weighed less than controls; the weight deficit reached 57% at weaning (P < 0.001). Both at the end of gestation and at weaning, they presented with an aberrant gastric oxyntic mucosa formation with loss of cell polarity, anarchic cell migration, abnormal progenitor differentiation, apoptosis, and signs of surface layer erosion. Ghrelin cells were abnormally located in the ...Continue Reading

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Citations

Mar 12, 2013·Trends in Endocrinology and Metabolism : TEM·Jean-Louis GuéantJean-Luc Daval
Jul 17, 2012·The British Journal of Nutrition·Aude BressenotLaurent Peyrin-Biroulet
Apr 2, 2011·World Journal of Gastroenterology : WJG·Penny L JefferySara K Linden
Sep 4, 2013·Pflügers Archiv : European journal of physiology·Jean-Louis GuéantRosa-Maria Guéant-Rodriguez
Apr 5, 2011·Molecular and Cellular Endocrinology·Penny JefferyMichael McGuckin
Feb 8, 2011·Autoimmunity Reviews·Siddharth BankaWilliam G Newman
Jan 5, 2011·Journal of Cellular and Molecular Medicine·Min ChenJean-Louis Guéant
Jan 16, 2013·The Journal of Nutritional Biochemistry·Emilie MartinezPatrick Brachet
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Feb 13, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carine Bossenmeyer-PouriéBernard Beck
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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