Methyl Donor Nutrients in Chronic Kidney Disease: Impact on the Epigenetic Landscape

The Journal of Nutrition
Denise MafraPaul G Shiels

Abstract

Epigenetic alterations, such as those linked to DNA methylation, may potentially provide molecular explanations for complications associated with altered gene expression in illnesses, such as chronic kidney disease (CKD). Although both DNA hypo- and hypermethylation have been observed in the uremic milieu, this remains only a single aspect of the epigenetic landscape and, thus, of any biochemical dysregulation associated with CKD. Nevertheless, the role of uremia-promoting alterations on the epigenetic landscape regulating gene expression is still a novel and scarcely studied field. Although few studies have actually reported alterations of DNA methylation via methyl donor nutrient intake, emerging evidence indicates that nutritional modification of the microbiome can affect one-carbon metabolism and the capacity to methylate the genome in CKD. In this review, we discuss the nutritional modifications that may affect one-carbon metabolism and the possible impact of methyl donor nutrients on the microbiome, CKD, and its phenotype.

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Citations

Aug 17, 2019·Biochemical Society Transactions·Paul G ShielsPeter Stenvinkel
Sep 24, 2020·Nature Reviews. Nephrology·Denise MafraPeter Stenvinkel
Sep 29, 2020·Frontiers in Endocrinology·Sarah BuchananPaul G Shiels
Sep 11, 2020·Nature Reviews. Genetics·Ziwei DaiJason W Locasale
Jun 18, 2021·Scientific Reports·Hannah CravenPaul G Shiels
Jul 29, 2021·The Biochemical Journal·Paul G ShielsPeter Stenvinkel

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