PMID: 9548415Apr 21, 1998Paper

Methyl-GAG, ifosfamide, methotrexate and etoposide (MIME) as salvage therapy for Hodgkin's disease: a prospective study

European Journal of Haematology
G EnbladB Glimelius

Abstract

This study presents the results of a prospective study of methyl-gag, ifosfamide, methotrexate and etoposide (MIME) as salvage regimen for Hodgkin's disease (HD) in Sweden. Sixty-four patients with recurrent or refractory HD were treated with MIME between July 1988 and December 1993. All patients except one had, earlier, been treated with and failed consecutive or alternating MOPP and ABVD. Median age was 37 yr (range 14-73). Twenty patients (31%) achieved a complete remission (CR) and 17 (27%) a partial remission (PR), giving an overall response rate of 58%. The 5-yr survival for all patients was 43%. In a multivariate analysis, the most important factors predicting a poor survival were the presence of extranodal disease at relapse, male gender and high age. Twenty-nine patients were treated with high-dose chemotherapy with stem-cell rescue after MIME. Those patients had a similar survival compared to the patients responding to MIME but not treated with high-dose chemotherapy. We conclude that MIME induces remissions in a high proportion of patients with recurrent and refractory HD with acceptable toxicity. The remissions probably need consolidation, but the nature of this consolidation is still controversial.

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Citations

May 31, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·C RodríguezE Ballesteros
Jun 20, 2002·European Journal of Haematology·Rose-Marie AminiGunilla Enblad
Oct 4, 2005·Pediatric Blood & Cancer·Robert S WimmerCindy L Schwartz
Jul 10, 1999·Current Opinion in Hematology·R G Bociek, J O Armitage
Feb 14, 2007·The Oncologist·Brian J Byrne, Jon P Gockerman
Jun 1, 2009·Expert Review of Hematology·David Sibon, Pauline Brice
Nov 6, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Fernández de LarreaE Carreras

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