Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice

Oncotarget
Jingjing LiChuanyong Guo

Abstract

Methyl jasmonate has recently been found to have anti-cancer activity. Methyl jasmonate detached hexokinase 2 from a voltage dependent anion channel causing a reduction in mitochondrial transmembrane potential that led to the release of cytochrome C and apoptosis inducing factor resulting in intrinsic apoptosis. Blocked adenosine triphosphate synthesis caused by mitochondrial injury hampered oxidative phosphorylation and led to cell necrosis. The results were applied to the in vivo treatment of nude mice with a satisfactory effect. Collectively, our results suggest that methyl jasmonate may be an adjuvant therapy for liver tumors due to its mechanism in cancer cells compared to that in normal cells: The major function is to inhibit glycolysis instead of changing aerobic metabolism.

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Citations

Oct 18, 2019·Antioxidants·Heloisa V Pereira-MarósticaAnacharis B Sá-Nakanishi
Jan 4, 2019·Genes & Cancer·Chae Young HanBenjamin K Tsang
Sep 14, 2018·Oxidative Medicine and Cellular Longevity·Anacharis B Sá-NakanishiJurandir F Comar
Jan 22, 2020·Journal of Bioenergetics and Biomembranes·Somayeh YousefiAli Akbar Pourfathollah
Sep 27, 2020·International Journal of Molecular Sciences·Shalini ManiKeshav K Singh
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona Jarocka-Karpowicz, Agnieszka Markowska
Aug 28, 2021·International Journal of Molecular Sciences·Iwona Jarocka-Karpowicz, Agnieszka Markowska

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Methods Mentioned

BETA
PCR
fluorescence microscopy
flow cytometry
flow
transfection
xenograft
co-immunoprecipitation
immunoprecipitation assay
protein assay
electrophoresis

Software Mentioned

Pro Plus
Compusyn
SPSS
Image

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