PMID: 9168150Apr 26, 1997Paper

Methyl mercury interactions with phospholipid membranes as reported by fluorescence, 31P and 199Hg NMR

Biochimica Et Biophysica Acta
L GiraultE J Drfourc

Abstract

Methylmercury (CH3Hg(II)) interactions with multilamellar vesicles of dimyristoyl(DM)- and dipalmitoyl(DP)-phosphatidylcholine (PC), -phosphatidic acid (PA), -phosphatidylglycerol (PG), -phosphatidylserine (PS) and -phosphatidylethanolamine (PE) have been investigated from the metal viewpoint by solution 199Hg-NMR and from the membrane side by diphenylhexatriene fluorescence polarization and solid state 31P-NMR. Results can be summarized as follows: (1) CH3Hg(II) strong binding to membranes results in a progressive decrease of the free CH3HgOH 199Hg-NMR isotropic signal and because of a slow exchange, in the NMR time scale, between free and bound methylmercury pools the lipid/water partition coefficients, K(lw), of the CH3HgOH species can be determined in the lamellar gel (fluid) phase. It is found: K(lw)(DMPC) approximately 2 +/- 2 (2 +/- 2); K(lw)(DMPE) approximately 7 +/- 3 (16 +/- 3); K(lw)(DMPG) = 170 +/- 10 (110 +/- 10); K(lw)(DMPS) = 930 +/- 50 (1250 +/- 60); K(lw)(DMPA) = 1250 +/- 60 (300 +/- 20). CH3Hg(II) interactions with membrane phospholipids are therefore electrostatic in nature and the phosphate moiety is proposed as a potential binding site. (2) The presence of CH3HgOH stabilizes the PG gel phase and destabilize...Continue Reading

References

Apr 1, 1989·Biophysical Journal·M Petersheim, J Sun
Mar 17, 1973·Biochemical and Biophysical Research Communications·R W ChenK G Hoekstra
Aug 1, 1982·Ecotoxicology and Environmental Safety·A BoudouD Georgescauld
Feb 1, 1984·Chemico-biological Interactions·R M LeblancJ Paiement

❮ Previous
Next ❯

Citations

May 16, 2000·Chemistry and Physics of Lipids·M Langner, K Kubica
May 2, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Magnus Jensen, Willy Nerdal
Mar 18, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mario SuwalskyHernán Cardenas
Jul 19, 2014·Chemistry and Physics of Lipids·Andrea StirpeLuigi Sportelli
Nov 30, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mario SuwalskyHernan Cárdenas
Dec 17, 2015·Physical Chemistry Chemical Physics : PCCP·Edison FlórezAlbeiro Restrepo
Oct 31, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Laís Pessanha de Carvalho, Edésio José Tenório de Melo
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Elham Zeini Jahromi, Jürgen Gailer
Aug 30, 2019·The Journal of Microbiology·Laís Pessanha de Carvalho, Edésio José Tenório de Melo
Sep 1, 2018·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Laís Pessanha de Carvalho, Edésio José Tenório de Melo
Mar 27, 2009·The Journal of Physical Chemistry. B·Marcin Broniatowski, Patrycja Dynarowicz-Łatka
May 13, 2018·Biochimica Et Biophysica Acta. General Subjects·Nicholas V C Ralston, Laura J Raymond

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.