Methylated circulating tumor DNA in blood: power in cancer prognosis and response

Endocrine-related Cancer
Kristina WartonGoli Samimi

Abstract

Circulating tumor DNA (ctDNA) in the plasma or serum of cancer patients provides an opportunity for non-invasive sampling of tumor DNA. This 'liquid biopsy' allows for interrogations of DNA such as quantity, chromosomal alterations, sequence mutations and epigenetic changes, and can be used to guide and improve treatment throughout the course of the disease. This tremendous potential for real-time 'tracking' in a cancer patient has led to substantial research efforts in the ctDNA field. ctDNA can be distinguished from non-tumor DNA by the presence of tumor-specific mutations and copy number variations, and also by aberrant DNA methylation, with both DNA sequence and methylation changes corresponding to those found in the tumor. Aberrant methylation of specific promoter regions can be a very consistent feature of cancer, in contrast to mutations, which typically occur at a wide range of sites. This consistency makes ctDNA methylation amenable to the design of widely applicable clinical assays. In this review, we examine ctDNA methylation in the context of monitoring disease status, treatment response and determining the prognosis of cancer patients.

References

Jun 22, 1999·British Journal of Cancer·J M SilvaF Bonilla
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Thierry LecomtePierre Laurent-Puig
Nov 28, 2002·Breast Cancer Research and Treatment·Qifeng YangKennichi Kakudo
Apr 3, 2003·Nature Reviews. Cancer·Peter W Laird
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thian-Sze WongAnthony Po-Wing Yuen
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick J BastianWilliam G Nelson
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
Nov 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Frank DiehlBert Vogelstein
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José Luis RamirezUNKNOWN Spanish Lung Cancer Group
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takuji MoriDave S B Hoon
Jul 5, 2006·Cancer Research·Takuji MoriDave S B Hoon
Aug 9, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jürgen R FischerHarald Lahm
Aug 16, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohammad O HoqueDavid Sidransky
Feb 7, 2007·Cancer Research·Valentina BollatiAllen S Yang
Nov 17, 2007·The Journal of Urology·Jörg EllingerPatrick J Bastian
Aug 2, 2008·Nature Medicine·Frank DiehlLuis A Diaz
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shigeki YagyuHajime Hosoi
Mar 5, 2009·Journal of Cancer Research and Clinical Oncology·Andreas-Claudius HoffmannJan Brabender
Mar 27, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Takatsugu OkegawaEiji Higashihara
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Thomas E LiggettVictor V Levenson
Jun 24, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Imen Miladi-AbdennadherRaja Mokdad-Gargouri
Sep 21, 2010·Journal of Translational Medicine·Mónica CastroMarta Sánchez-Carbayo
Jan 12, 2011·Breast Cancer Research and Treatment·Georg GöbelGünter Daxenbichler
Mar 10, 2011·Nature Medicine·Manuel Rodríguez-Paredes, Manel Esteller
Jun 4, 2011·Genes, Chromosomes & Cancer·Jane J PappasW E C Bradley
Jun 23, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christoph KneipDimo Dietrich
Sep 24, 2011·Nature Reviews. Cancer·Stephen B Baylin, Peter A Jones
Nov 26, 2011·Gynecologic Oncology·Céline MontavonPhilippa M O'Brien
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga

❮ Previous
Next ❯

Citations

Apr 6, 2016·Future Oncology·Giovanna TrecateRosaria Orlandi
Aug 12, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·C ParisiE S Lianidou
May 11, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·C NadalDavid Tougeron
Nov 29, 2017·The AAPS Journal·Volker M LauschkeMagnus Ingelman-Sundberg
Dec 23, 2017·Genome Medicine·Martin WidschwendterHarri Lempiäinen
Jan 19, 2018·Molecular Cancer·Su Yin LimHelen Rizos
Mar 1, 2019·JNCI Cancer Spectrum·Rachel M GolonkaMatam Vijay-Kumar
Aug 25, 2019·Cells·Marzena CiechomskaWlodzimierz Maslinski
Feb 14, 2020·Experimental Biology and Medicine·Shumei ZhangYan Zhang
May 5, 2020·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mariana Cartaxo AlvesAuro Del Giglio
Jun 22, 2018·Oncotarget·Dipesh Kumar YadavTingbo Liang
Aug 8, 2018·International Journal of Oncology·Alessia FinottiRoberto Gambari
Aug 8, 2019·International Journal of Molecular Sciences·Dana DvorskáZuzana Danková
Sep 25, 2020·British Journal of Cancer·Laura KellerKlaus Pantel
Dec 10, 2016·Cancer Nanotechnology·Harry W CliffordJohn W Cassidy
Apr 28, 2018·Scientific Reports·Lifei ZhuHong Chen
Jul 14, 2018·Frontiers of Medicine·Xin Qin, Ping Zhang
Aug 2, 2019·Reviews in Endocrine & Metabolic Disorders·Gitta BoonsKen Op de Beeck
Oct 17, 2019·Cancers·Jung-A ChoiJae-Hoon Kim
Nov 2, 2019·Critical Reviews in Clinical Laboratory Sciences·Eleni Tzanikou, Evi Lianidou
Apr 24, 2018·Clinical Epigenetics·Lieselot CroesKen Op de Beeck
Jun 24, 2020·International Journal of Colorectal Disease·Rui WangFeng Liu
May 18, 2017·Nature Reviews. Gastroenterology & Hepatology·Nisha PadmanabhanPatrick Tan
Jul 8, 2017·BioMed Research International·Krysta Mila CoylePaola Marcato
May 13, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Fajiu LiChenghong Li
Sep 27, 2018·International Journal of Molecular Sciences·José Marrugo-RamírezJosep Samitier
Nov 10, 2018·Nature Reviews. Genetics·Ellen HeitzerMichael R Speicher
May 28, 2019·Journal of Cellular Biochemistry·Fatemeh KhatamiSeyed Mohammad Tavangar

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
PCR
blood draw
methylation assay

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Lin LiJiafu Ji
Mini Reviews in Medicinal Chemistry
Ting YeJingyuan Fang
Frontiers in Molecular Biosciences
Kristina Warton, Goli Samimi
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Andreas WidschwendterMartin Widschwendter
© 2022 Meta ULC. All rights reserved