Methylation and repeats in silent and nonsense mutations of p53

Mutation Research
Sofia KouidouNicos Maglaveras

Abstract

All exonic CG sequences in p53 are methylated; this epigenetic modification is correlated with frequent G:C-->A:T transitions in p53. Recent reports reveal the presence in p53 of non-CG methylation in CC and CCC sequences, complementary to sites of selective guanosine adduct formation (GG and GGG), and the association of genetic instability with methylation at repetitive sequences. We presently investigated the distribution of methylation sites and repetitive elements in silent and nonsense p53 mutations (2051) among the IARC's TP53 somatic mutation database for exons 5-8. Silent mutations are nonrandom, but mostly involve G:C-->A:T transitions (62%); in particular C-->T mutations (39% of all silent mutations) are mostly correlated with CC and CCC sequences, while G-->A mutations with GG sequences. Sequence analysis of all non-G:C-->A:T silent mutations reveals the frequent formation of new methylation sites (CG), new CCC and GGG sequences in the resulting sequence, refinement of symmetry elements at interrupted microsatellite-like sequences and formation of small repeats (55.3%). The G:C-->A:T silent mutations characterize cancers associated with cigarette smoking (e.g. bladder or lung and bronchus cancer versus colorectal can...Continue Reading

References

Aug 8, 1997·Biochimica Et Biophysica Acta·G P Pfeifer, G P Holmquist
Mar 11, 2000·Genetica·P CatastiG Gupta
Jun 6, 2000·Mutation Research·G P Pfeifer
Jul 27, 2000·Annals of the New York Academy of Sciences·T Soussi
Dec 7, 2000·Mutation Research·B S Strauss
May 15, 2002·Human Mutation·Magali OlivierPierre Hainaut
Jun 28, 2002·Nucleic Acids Research·Cristian CañestroRicard Albalat
Aug 13, 2002·Current Genetics·Johannes Wöstemeyer, Anne Kreibich
Aug 15, 2002·Genome Research·Kerrie Nichol, Christopher E Pearson
Jul 29, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rebecca E WatsonJay I Goodman
Aug 21, 2003·Journal of the National Cancer Institute·Xifeng WuMargaret R Spitz
Jan 20, 2004·Carcinogenesis·P D Lewis, J M Parry
Jan 22, 2004·British Journal of Cancer·C J Stein, G A Colditz
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Catherine CohetPaolo Boffetta
Mar 6, 2004·Cancer Metastasis Reviews·William M Grady
Dec 31, 2004·American Journal of Human Genetics·Kerrie Nichol EdamuraChristopher E Pearson
Jan 15, 2005·International Journal of Epidemiology·Volker MaiArthur Schatzkin
Mar 15, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Y-C ChenD C Christiani
Mar 31, 2005·Proceedings of the National Academy of Sciences of the United States of America·Julien MeunierLaurent Duret
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Manel Esteller
Aug 30, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sofia KouidouGeorgios Tzimagiorgis

❮ Previous
Next ❯

Citations

May 17, 2007·Breast Cancer Research and Treatment·Sofia KouidouNicos Maglaveras
Apr 28, 2007·Nature Clinical Practice. Oncology·Owen J SansomAlan R Clarke
Jul 1, 2010·Molekuliarnaia biologiia·O V DiachenkoIa I Bur'ianov
Aug 12, 2009·Future Oncology·Liang ChengAntonio Lopez-Beltran
Dec 23, 2009·FEBS Letters·Cheng-Hong YangHsueh-Wei Chang
Nov 3, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Sun ShuzhenYang Xiu-Peng
Apr 22, 2009·Journal of Cellular and Molecular Medicine·Roman HrstkaBorivoj Vojtesek
Jul 17, 2013·The Plant Journal : for Cell and Molecular Biology·Rachele FalchiMichele Morgante

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Carcinoma, Bronchogenic

Bronchogenic Carcinoma is a malignant lung cancer arising in the epithelium of the bronchus or bronchiole. Discover the latest research on Bronchogenic Carcinoma here.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Breast Cancer Research and Treatment
Sofia KouidouNicos Maglaveras
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Sofia KouidouGeorgios Tzimagiorgis
Proceedings of the National Academy of Sciences of the United States of America
Bernard H RamsahoyeR Jaenisch
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jian YuJingde Zhu
© 2022 Meta ULC. All rights reserved