Methylation-Based Biological Age and Breast Cancer Risk

Journal of the National Cancer Institute
Jacob K KresovichJack A Taylor

Abstract

Age is one of the strongest predictors of cancer, chronic disease, and mortality, but biological responses to aging differ among people. Epigenetic DNA modifications have been used to estimate "biological age," which may be a useful predictor of disease risk. We tested this hypothesis for breast cancer. Using a case-cohort approach, we measured baseline blood DNA methylation of 2764 women enrolled in the Sister Study, 1566 of whom subsequently developed breast cancer after an average of 6 years. Using three previously established methylation-based "clocks" (Hannum, Horvath, and Levine), we defined biological age acceleration for each woman by comparing her estimated biological age with her chronological age. Hazard ratios and 95% confidence intervals for breast cancer risk were estimated using Cox regression models. All statistical tests were two-sided. Each of the three clocks showed that biological age acceleration was statistically significantly associated with increased risk of developing breast cancer (5-year age acceleration, Hannum's clock: hazard ratio [HR] = 1.10, 95% confidence interval [CI] = 1.00 to 1.21, P = .04; Horvath's clock: HR = 1.08, 95% CI = 1.00 to 1.17, P = .04; Levine's clock: HR = 1.15, 95% CI = 1.07 to...Continue Reading

References

Dec 2, 1999·Journal of Clinical Epidemiology·W E BarlowS Izumi
Nov 3, 2004·The Journal of Clinical Investigation·Janakiraman KrishnamurthyNorman E Sharpless
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
Jan 4, 2007·Nature Genetics·Martin WidschwendterPeter W Laird
Mar 12, 2010·Genome Research·Andrew E TeschendorffMartin Widschwendter
Feb 4, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Annette L FitzpatrickAbraham Aviv
Jul 7, 2011·PloS One·Sven BocklandtEric Vilain
May 10, 2012·BMC Bioinformatics·Eugene Andres HousemanKarl T Kelsey
May 17, 2012·Nature Reviews. Molecular Cell Biology·Ergün Sahin, Ronald A DePinho
Sep 15, 2012·Current Biology : CB·Teresa Niccoli, Linda Partridge
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Dec 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Morgan E Levine
Jan 15, 2013·Aging Cell·Alice C HollyLorna W Harries
Mar 5, 2013·The Journal of Clinical Investigation·Ana Bratic, Nils-Göran Larsson
Aug 7, 2013·Human Molecular Genetics·Andrew E TeschendorffStephan Beck
Oct 22, 2013·Genome Biology·Steve Horvath
Jan 3, 2014·The Journal of Clinical Investigation·Jean-Pierre Issa
Feb 5, 2014·Genome Biology·Carola Ingrid WeidnerWolfgang Wagner
Oct 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Steve HorvathJochen Hampe
Jan 31, 2015·Genome Biology·Riccardo E MarioniIan J Deary
Jul 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniel W BelskyTerrie E Moffitt
Jul 22, 2015·Cancer·Alexandra J WhiteDale P Sandler
Sep 19, 2015·Nucleic Acids Research·Zongli XuJack A Taylor
Oct 23, 2015·Nature Communications·Marjolein J PetersAndrew D Johnson
Nov 26, 2015·Aging Cell·Lene ChristiansenKaare Christensen
Dec 15, 2015·Journal of Proteome Research·Johannes HertelHans Jörgen Grabe
Apr 15, 2016·EBioMedicine·Yinan ZhengLifang Hou
Jul 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Morgan E LevineSteve Horvath
Feb 28, 2017·JAMA Oncology·UNKNOWN Telomeres Mendelian Randomization CollaborationGeorge Davey Smith
Mar 5, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Srikant AmbatipudiZdenko Herceg
Apr 12, 2017·EBioMedicine·Juulia JylhäväSara Hägg
May 10, 2017·American Journal of Epidemiology·Alexandra J WhiteDale P Sandler
Jan 5, 2018·PLoS Genetics·Rosa Ana Risques, Scott R Kennedy

❮ Previous
Next ❯

Citations

Feb 23, 2019·Journal of the National Cancer Institute·Brock C Christensen
Jul 10, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Melanie Ehrlich
Oct 11, 2019·Human Reproduction·Jacob K KresovichJack A Taylor
Jan 18, 2020·JAMA Network Open·Jacob K KresovichJack A Taylor
Jan 17, 2020·Human Molecular Genetics·Lucas A SalasBrock C Christensen
Sep 12, 2019·American Journal of Epidemiology·Priya DuggalTerri H Beaty
Dec 12, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Cuicui WangClarice R Weinberg
Mar 14, 2020·Epidemiology·Jacob K KresovichJack A Taylor
Dec 19, 2019·Aging·Jacob K KresovichJack A Taylor
Aug 18, 2020·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Christina A MarkunasJack A Taylor
Sep 25, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Maeve KielyXiaohong R Yang
May 28, 2020·Frontiers in Aging Neuroscience·Monica A WagnerYvette P Conley
Dec 24, 2019·Frontiers in Bioengineering and Biotechnology·Tongtong ZhuShangwei Ning
Mar 19, 2020·BMC Bioinformatics·Joshua J LevyBrock C Christensen
Oct 10, 2019·Environmental Health Perspectives·Alexandra J WhiteDale P Sandler
Nov 12, 2020·Experimental Biology and Medicine·Xi HeJingshan Shi
Nov 4, 2020·The Journal of Clinical Endocrinology and Metabolism·Alexa C O MedicaH Irene Su
Dec 15, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Mei ChungDominique S Michaud
Jan 5, 2021·International Journal of Cancer. Journal International Du Cancer·Chung-Ho E Lau, Oliver Robinson
Aug 7, 2019·Environment International·Alexandra J WhiteDale P Sandler
Nov 22, 2020·Mitochondrion·Chelsea AndersonHazel B Nichols
Jan 15, 2021·JNCI Cancer Spectrum·Pierre-Antoine DuguéRoger L Milne
Mar 12, 2021·American Journal of Epidemiology·Jacob K KresovichJack A Taylor
Nov 25, 2020·Trends in Cancer·Ariel A Hippen, Casey S Greene
Apr 16, 2021·Nature Communications·Sandra L Romero-CordobaAlfredo Hidalgo-Miranda
Jun 13, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Rachel M LuciaHannah Lui Park
May 27, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jacob K KresovichJack A Taylor
Aug 29, 2021·European Journal of Epidemiology·Alessandro GialluisiUNKNOWN Moli-sani Study Investigators
Oct 1, 2021·GeroScience·Anna J JasinskaSteve Horvath
Oct 13, 2021·The American Journal of Clinical Nutrition·Jacob K KresovichJack A Taylor
Sep 21, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tiina FöhrElina Sillanpää
Oct 1, 2021·The American Journal of Clinical Nutrition·Nicholas A KoemelMichael R Skilton
Aug 20, 2021·Molecular Oncology·Jacob K KresovichJack A Taylor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.