Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma

Oncotarget
Ram Mohan Ram Kumar, Nina Felice Schor

Abstract

Neuroblastoma (NB), a developmental cancer, is often fatal, emphasizing the need to understand its pathogenesis and identify new therapeutic targets. The heterogeneous pathological and clinical phenotype of NB underscores the cryptic biological and genetic features of this tumor that result in outcomes ranging from rapid progression to spontaneous regression. Despite recent genome-wide mutation analyses, most primary NBs do not harbor driver mutations, implicating epigenetically-mediated gene regulatory mechanisms in the initiation and maintenance of NB. Aberrant epigenomic mechanisms, as demonstrated by global changes in DNA methylation signatures, acetylation, re-distribution of histone marks, and change in the chromatin architecture, are hypothesized to play a role in NB oncogenesis. This paper reviews the evidence for, putative mechanisms underlying, and prospects for therapeutic targeting of NB oncogenesis related to DNA methylation.

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Citations

May 11, 2021·Frontiers in Cell and Developmental Biology·Aleksandar KrsticDavid J Duffy

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Methods Mentioned

BETA
methylation profiling
xenograft
acetylation
xenografts

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