Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

Nature Structural & Molecular Biology
Erin M GreenOr P Gozani

Abstract

Methylation of histones is central to chromatin regulation, and thus previously unknown mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here we identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast. Set5's enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses.

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Citations

Mar 16, 2013·Trends in Biochemical Sciences·Steven G Clarke
Mar 22, 2014·PLoS Computational Biology·Teresa SzczepińskaMaga Rowicka
Oct 26, 2012·The FEBS Journal·Jason K K Low, Marc R Wilkins
Jan 21, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Glòria Mas MartínAshby J Morrison
Jun 13, 2012·Nucleus·Erin M GreenOr Gozani
Oct 23, 2016·Journal of Molecular Biology·Deepika JaiswalErin M Green
Dec 3, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Meagan JezekErin M Green
Apr 30, 2017·Molecular & Cellular Proteomics : MCP·Litong NieMinjia Tan
May 23, 2014·Nature·Pawel K MazurOr Gozani
Aug 28, 2013·Genetics·Meru J SadhuJasper Rine
Aug 3, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Olivier Binda
Dec 23, 2017·FEMS Yeast Research·Gesine HoffmannAnn E Ehrenhofer-Murray
Dec 14, 2018·Current Genetics·Khoa Tran, Erin M Green
May 4, 2017·The Journal of Biological Chemistry·Aoi MorimotoYusuke Inoue
Mar 3, 2019·Cells·Meagan Jezek, Erin M Green
Aug 17, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Anagh RayRonita Nag Chaudhuri
Oct 11, 2020·Current Genetics·Safia Mahabub SautyKrassimir Yankulov
Jul 6, 2021·The Journal of Biological Chemistry·Ryan J Separovich, Marc R Wilkins

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Methods Mentioned

BETA
dot blot
co-immunoprecipitation
acetylation

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