Methylation of progesterone receptor isoform A promoter in normal breast tissue: An epigenetic link between early age at menarche and risk of breast cancer?

Journal of Cellular Biochemistry
Abdolreza DaraeiJavad Tavakkoly-Bazzaz

Abstract

Emerging evidence indicates that some altered patterns of methylation that occur in breast tumors may also be found in breast tissue of healthy women in relation to the breast cancer (BC) risk factors. Progesterone receptor (PR) isoform α is a crucial regulator of breast hormone responsiveness and its hypermethylation plays an important role in the initiation and development of breast tumors. However, such a methylation change in healthy women and its link with the different risk factors has not yet been investigated. In the present study, we aimed to examine the relationship of possible methylation changes within a critical region in the promoter CpG island of PGR-α (progesterone receptor α) gene in the healthy women with a set of reproductive and nonreproductive BC risk factors. The breast tissues were collected from 120 cancer-free women who had undergone cosmetic mammoplasty. The genomic DNA was extracted from the breast tissues and the methylation level of PGR-α promoter CpG island was determined by using MeDIP-qPCR assay. Using regression analysis, we found that increasing menarche age is inversely associated with the high methylation of PGR-α promoter ( β = -0.790, SE = 0.362; P = 0.031). Although lactating women had mor...Continue Reading

References

Jul 1, 1995·Annals of Epidemiology·F Clavel-ChapelonR Renaud
May 20, 2000·Journal of Mammary Gland Biology and Neoplasia·R G LapidusN E Davidson
Mar 7, 2002·Journal of the National Cancer Institute·Masahiro SasakiRajvir Dahiya
Aug 6, 2002·Journal of Mammary Gland Biology and Neoplasia·Leslie Bernstein
Nov 25, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Jose RussoIrma H Russo
Nov 26, 2003·Journal of Mammary Gland Biology and Neoplasia·Orla M ConneelyJohn P Lydon
Nov 23, 2006·The Journal of Steroid Biochemistry and Molecular Biology·J Russo, Irma H Russo
Jan 17, 2008·Critical Reviews in Eukaryotic Gene Expression·Anastasia KariaginaSandra Z Haslam
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary Beth TerryEzra Susser
Oct 10, 2008·Archives of Toxicology·Mihi YangKeun-Young Yoo
Feb 3, 2009·Annals of Epidemiology·Monika M WahiSteven B Goldin
Feb 5, 2009·British Journal of Cancer·G K ReevesUNKNOWN Million Women Study Collaborators
Oct 6, 2009·Journal of Cellular and Molecular Medicine·R G DumitrescuP G Shields
Oct 29, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mia M GaudetMark E Sherman
Dec 25, 2010·Cancer Causes & Control : CCC·Amanda I PhippsChristopher I Li
Apr 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thushangi N PathirajaSteffi Oesterreich
Mar 10, 2012·Nature Protocols·Oluwatosin TaiwoLee M Butcher
Jun 21, 2012·Breast Cancer Research : BCR·Rebecca J WattersSteffi Oesterreich
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Pantea IzadiNateghi Mohammad Reza
Nov 8, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Kevin C JohnsonBrock C Christensen
Nov 28, 2013·PloS One·Christiana A DemetriouPaolo Vineis
Jan 31, 2014·Breast Cancer Research and Treatment·Kristin N AndersonMaria Elena Martinez
Sep 23, 2014·Breast Cancer Research and Treatment·Sagar GhoshRong Li
Aug 19, 2015·Trends in Endocrinology and Metabolism : TEM·Christoforos Thomas, Jan-Åke Gustafsson
Jul 15, 2017·Genetic Testing and Molecular Biomarkers·Abdolreza DaraeiJavad Tavakkoly-Bazzaz

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Citations

Oct 17, 2019·International Journal of Molecular Sciences·Milad BastamiZiba Nariman-Saleh-Fam

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