Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma

Cancer Genetics and Cytogenetics
Mariana Bohns MichalowskiDominique Plantaz

Abstract

Ependymomas (EP) represent the third most frequent type of central nervous system (CNS) tumor of childhood, after astrocytomas and medulloblastomas. No prognostic biological markers are available, and differentiation from choroid plexus papilloma (CPP) is difficult. The present objective was, for a sample of 27 children with intracranial EP and 7 with CPP, to describe and compare the methylation status of 19 genes (with current HUGO symbol, if any): p15INK4a (CDKN2B), p16INK4a and p14ARF (both CDKN2A), APC, RB1, RASSF1A (RASSF1), BLU (ZMYND10) FHIT, RARB, MGMT, DAPK (DAPK1), ECAD (CDH1), CASP8, TNFRSF10C, TNFRSF10D, FLIP (CFLAR), INI1 (SMARCB1), TIMP3, and NF2. Three adult corteses were used as a control. We detected a similar percentage of methylated tumors in both groups (71% in CPP and 77% in EP). No gene was methylated in that control group. RASSF1A was the most frequently methylated gene in both benign tumors (66%) and EP (56%). The genes associated with apoptosis were methylated in both groups of tumors. The percentages of TRAIL pathway genes (CASP8, TFRSF10C, and TFRSF10D) methylated were 30, 9.5, and 36.4%, respectively, in ependymomas and 50, 50, and 16.7%, respectively, in choroid plexus papillomas. No other gene was ...Continue Reading

References

Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
Nov 28, 2000·Annual Review of Genetics·A G Knudson
Mar 21, 2001·Human Molecular Genetics·S B BaylinJ G Herman
May 17, 2002·The Journal of Pathology·Judith W M JeukenPieter Wesseling
Dec 11, 2002·The Lancet Oncology·Yuri PekarskyCarlo M Croce
Jun 27, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Gonzalez-GomezJ A Rey
Sep 25, 2003·Genes, Chromosomes & Cancer·Max M van NoeselRogier Versteeg
Nov 14, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert T PuDouglas P Clark
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ivy H N WongPaul K H Tam
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ozlem TopalogluChul-so Moon
Sep 3, 2004·Nature Reviews. Cancer·Steven A Belinsky
Sep 4, 2004·Indian Journal of Pediatrics·Abhishek AgarwalA D Sehgal
Jul 27, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F de FraipontM C Favrot

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Citations

Jun 19, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Stephen C Mack, Michael D Taylor
Jul 15, 2009·Acta Neuropathologica·Norman L Lehman
Sep 20, 2011·Cellular and Molecular Neurobiology·Gulsah CecenerSahsine Tolunay
Jul 17, 2012·Current Treatment Options in Oncology·Karen D Wright, Amar Gajjar
Apr 29, 2010·Current Neurology and Neuroscience Reports·Mark R GilbertRiccardo Soffietti
Dec 12, 2012·Current Oncology Reports·Emma B Holliday, Erik P Sulman
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hehuang XieMarcelo B Soares
Aug 3, 2011·Journal of Neurosurgery. Pediatrics·Claudia M C FariaPaul Kongkham
Apr 24, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G TamburriniC Di Rocco
Oct 1, 2011·Chinese Journal of Cancer·Yuan YaoMichael D Taylor
Apr 21, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Isaac YangNeil A Martin
Jan 29, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Hui-Hua CaiHan-Lin Zhao
Dec 17, 2015·Brain Tumor Pathology·Yujin LeeSung-Hye Park
Nov 27, 2007·Cancer Genetics and Cytogenetics·Roberta Losi-GuembarovskiIlce M S Cólus
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Lu-Ting KuoYong-Kwang Tu
Jun 16, 2007·Pediatric Blood & Cancer·Mariana Bohns MichalowskiMarie-Christine Favrot
Feb 26, 2013·Brain Pathology·Stephen C MackMichael D Taylor
Jan 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Sexton-OatesR Saffery
Oct 22, 2008·Expert Review of Neurotherapeutics·Luke B HessonFarida Latif
Jan 1, 2011·Cancers·Irfan A Qureshi, Mark F Mehler
May 30, 2007·Oncogene·L B HessonF Latif
Nov 8, 2008·Current Opinion in Neurology·Roberta RudàRiccardo Soffietti
Nov 2, 2012·Neuromolecular Medicine·Anastasia SpyropoulouAthanasios G Papavassiliou
Mar 8, 2013·Journal of Neuro-oncology·Michael SafaeeAndrew T Parsa
Sep 6, 2011·Current Opinion in Oncology·Jacques GrillCéline Ferreira
Sep 17, 2008·Journal of Neuro-oncology·Martin HasselblattMichael C Frühwald
Sep 18, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Chang-Hyun LeeChi Heon Kim
Jun 18, 2009·Molecular Cancer Research : MCR·John-Paul KildayRichard Grundy
Sep 20, 2007·Journal of Cell Science·Howard DonningerGeoffrey J Clark

❮ Previous
Next ❯

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