Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features

Cancer Letters
B A Shannon, B Iacopetta

Abstract

The methylation status of seven cancer-related genes was investigated in a series of 58 colorectal cancers, 18 of which showed the microsatellite instability (MSI+) phenotype. Methylation of the hMLH1, p16 and MDR1 genes was found in 23, 29 and 28% of tumors, respectively. None of the tumors showed methylation of the TS, ATM, PARP or p21 genes. Methylation of the hMLH1, p16 and MDR1 genes was more frequent and more concordant in MSI+ compared to MSI- tumors (P<0.001) and was also strongly associated with poor histological differentiation (P<0.001). There were trends for associations between methylation at one or more of these loci and proximal tumor location, advanced Dukes' stage and the presence of wild-type p53 (P=0.06 for each).

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Citations

Feb 21, 2013·International Journal of Colorectal Disease·Luciano Delgado-PlasenciaJuan J González-Aguilera
Oct 22, 2003·Experimental Cell Research·Emma K Baker, Assam El-Osta
Oct 13, 2006·Current Opinion in Gastroenterology·Lanlan Shen, Jean-Pierre J Issa
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Mar 27, 2010·International Journal of Radiation Oncology, Biology, Physics·Barbara HofstetterI Frank Ciernik
Mar 4, 2008·Gastroenterology Clinics of North America·Mitchell S Cappell
Nov 14, 2015·Pathology, Research and Practice·Luciano Delgado-PlasenciaVicente Medina-Arana
Aug 7, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·John M MariadasonLeonard H Augenlicht
Nov 6, 2004·The Medical Clinics of North America·Mitchell S Cappell
Mar 8, 2005·Clinics in Laboratory Medicine·Mitchell S Cappell
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Mar 4, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna M DahlinBethany R Van Guelpen
Nov 3, 2004·Gastroenterology·Asif Rashid, Jean Pierre J Issa

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