Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups

Neuro-oncology
Christian ThomasMartin Hasselblatt

Abstract

Choroid plexus tumors are intraventricular neoplasms derived from the choroid plexus epithelium. A better knowledge of molecular factors involved in choroid plexus tumor biology may aid in identifying patients at risk for recurrence. Methylation profiles were examined in 29 choroid plexus papillomas (CPPs, WHO grade I), 32 atypical choroid plexus papillomas (aCPPs, WHO grade II), and 31 choroid plexus carcinomas (CPCs, WHO grade III) by Illumina Infinium HumanMethylation450 Bead Chip Array. Unsupervised hierarchical clustering identified 3 subgroups: methylation cluster 1 (pediatric CPP and aCPP of mainly supratentorial location), methylation cluster 2 (adult CPP and aCPP of mainly infratentorial location), and methylation cluster 3 (pediatric CPP, aCPP, and CPC of supratentorial location). In methylation cluster 3, progression-free survival (PFS) accounted for a mean of 72 months (CI, 55-89 mo), whereas only 1 of 42 tumors of methylation clusters 1 and 2 progressed (P< .001). On stratification of outcome data according to WHO grade, all CPCs clustered within cluster 3 and were associated with shorter overall survival (mean, 105 mo [CI, 81-128 mo]) and PFS (mean, 55 mo [CI, 36-73 mo]). The aCPP of methylation cluster 3 also pro...Continue Reading

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Citations

May 28, 2016·Acta Neuropathologica Communications·Maria-Magdalena GeorgescuJack M Raisanen
Mar 13, 2018·Pediatric Blood & Cancer·Wafik Zaky, Jonathan L Finlay
Jan 20, 2020·Neuropathology and Applied Neurobiology·E Perez, D Capper
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Aug 15, 2019·Clinical Epigenetics·Malgorzata PienkowskaDavid Malkin
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Jan 9, 2019·Acta neurochirurgica·Patricia Puerta RoldánAntonio Guillén Quesada
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Sep 17, 2021·Journal of Neuro-oncology·Chantelle Browne-FarmerUte Bartels
Aug 31, 2021·Neuropathology and Applied Neurobiology·Arnault Tauziède-EspariatMartin Hasselblatt

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