Methylation-regulated expression of cancer testis antigens in primary effusion lymphoma: immunotherapeutic implications

Journal of Cellular Physiology
Luana CalabròMichele Maio

Abstract

Primary effusion lymphoma (PEL) is a large B-cell neoplasm with an unfavorable prognosis and limited therapeutic options. In this study, cancer testis antigens (CTA) were investigated as potential immunotherapeutic targets in patients with PEL. Baseline expression of a panel of 11 CTA was highly heterogeneous among five PEL cell lines. In particular, the investigated CTA were not expressed in BC-2 and BC-3 cells, while BC-1, HBL-6, and BCBL-1 cells tested positive for 6, 8, and 9 CTA, respectively. The DNA hypomethylating agent 5-aza-2'-deoxycytdine (5-AZA-CdR) invariably induced or up-regulated the expression of all investigated CTA in all cell lines analyzed. The de novo expression of CTA was still detectable at mRNA and protein level at least 2 months after the end of 5-AZA-CdR treatment. These findings, and the concomitant up-regulation of HLA-class I antigens and ICAM-1 by 5-AZA-CdR, support its clinical use to set-up innovative chemo-immunotherapeutic approaches in PEL.

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Citations

Nov 10, 2012·Cancer Immunology, Immunotherapy : CII·Sandra CoralMichele Maio
Mar 1, 2010·Genes & Cancer·Stefano AmatoriMirco Fanelli
Sep 1, 2009·The American Journal of Pathology·Andrew G Muntean, Jay L Hess
Apr 27, 2007·Journal of Cellular Physiology·Luca SigalottiMichele Maio
Feb 4, 2010·Journal of Cellular Physiology·Elisabetta FrattaMichele Maio
Oct 8, 2005·Seminars in Oncology·Luca SigalottiMichele Maio
Oct 8, 2005·Seminars in Oncology·Valter GatteiMichele Maio
Jan 22, 2008·Journal of Cellular Physiology·Luca SigalottiMichele Maio
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ester FonsattiMichele Maio

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