journal cover

Methylation-sensitive expression of a DNA demethylase gene serves as an epigenetic rheostat

PLoS Genetics

Apr 1, 2015

Ben P WilliamsMary Gehring

Abstract

Genomes must balance active suppression of transposable elements (TEs) with the need to maintain gene expression. In Arabidopsis, euchromatic TEs are targeted by RNA-directed DNA methylation (RdDM). Conversely, active DNA demethylation prevents accumulation of methylation at genes proxi...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Biochemical Pathway
Hydrogen sulfite
DNA Methylation [PE]
Histone antigen
Exons
Protein Methylation
Genome
Genes
HIF1A wt Allele
28
2
122
Paper Details
References
  • References59
  • Citations30
12345...
  • References59
  • Citations30
123

Similar Papers Found In These Feeds

Transposable Elements

Transposable elements (tes) have profound effects on the structure, function and evolution of their host genomes.

DNA Methylation

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Open Access Genomics Journals

Discover the latest genomics research in this collection of the top open access genomics journals.

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

Epigenetic Modifications of RNA

Epitranscriptomics is a scientific field that studies epigenetic modifications on RNA. Here is the latest research pertaining to epitranscriptomics and mechanisms that underlie RNA modifications.

Global Screens and Gene Activity (Keystone)

Genome-wide screens allow researchers to look at the whole picture of gene activity that is going on in the cell. Discover the latest research using genome-wide screens in this feed.

DNA Methylation and Cancer (Keystone)

DNA methylation in cancer plays a variety of roles, helping to change the healthy regulation of gene expression to a disease pattern. Discover the latest research on DNA methylation and cancer by following this feed.

Post-transcriptional RNA modifications

Post-transcriptional RNA modifications can be dynamic and might have functions beyond fine-tuning the structure and function of rna.

Transposons for Gene Editing

Transposons can replicate and spread through the host’s genome and therefore be used as a genetic tool for analysis of gene function. Discover the latest research on the use of transposons for gene editing here.

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

DNA Methylation (Keystone)

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Histone Methyltransferases (Keystone)

Histone methyltransferases, as chromatin modifiers, regulate the transcriptomic landscape in normal development as well as in diseases such as cancer. This feed captures the latest research.

Global Screens and Gene Activity (Keystone)

Genome-wide screen allows researchers to look at the whole picture of gene activity that is going on in the cell. Discover the latest research here.

Heterochromatin Function

Heterochromatin is condensed chromatin that was previously believed to be inaccessible for transcription, although this has been disproven. Heterochromatin plays a role in gene expression. Find the latest research on heterochromatin here.

Nucleolar Dynamics

The nucleolus is the site of ribosome biogenesis, making ribosomal subunits from proteins and ribosomal RNA. Discover the latest research on nucleolar dynamics here.

Histone Methyltransferases

Histone methyltransferases, as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here is the latest research.

Epigenetics

Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.

Heterochromatin Function (Keystone)

Heterochromatin is condensed chromatin that was previously believed to be inaccessible for transcription, although this has been disproven. Heterochromatin plays a role in gene expression. Find the latest research on heterochromatin here.

Epigenetics (Keystone)

Epigenetics is the study of heritable changes in gene expression that do not involve alteration of the DNA sequence. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Regulatory link between DNA methylation and active demethylation in Arabidopsis

Proceedings of the National Academy of Sciences of the United States of AmericaMarch 4, 2015
Mingguang LeiJian Kang Zhu
PLoS Genetics

A Pre-mRNA-splicing factor is required for RNA-directed DNA methylation in Arabidopsis

PLoS GeneticsSeptember 27, 2013
Chao-Feng HuangJian Kang Zhu
© 2020 Meta ULC. All rights reserved

Methylation-sensitive expression of a DNA demethylase gene serves as an epigenetic rheostat

PLoS Genetics

Apr 1, 2015

Ben P WilliamsMary Gehring

PMID: 25826366

DOI: 10.1371/journal.pgen.1005142

Abstract

Genomes must balance active suppression of transposable elements (TEs) with the need to maintain gene expression. In Arabidopsis, euchromatic TEs are targeted by RNA-directed DNA methylation (RdDM). Conversely, active DNA demethylation prevents accumulation of methylation at genes proxi...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Biochemical Pathway
Hydrogen sulfite
DNA Methylation [PE]
Histone antigen
Exons
Protein Methylation
Genome
Genes
HIF1A wt Allele
28
2
122

Similar Papers Found In These Feeds

Transposable Elements

Transposable elements (tes) have profound effects on the structure, function and evolution of their host genomes.

DNA Methylation

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Regulatory link between DNA methylation and active demethylation in Arabidopsis

Proceedings of the National Academy of Sciences of the United States of AmericaMarch 4, 2015
Mingguang LeiJian Kang Zhu
PLoS Genetics

A Pre-mRNA-splicing factor is required for RNA-directed DNA methylation in Arabidopsis

PLoS GeneticsSeptember 27, 2013
Chao-Feng HuangJian Kang Zhu
Paper Details
References
  • References59
  • Citations30
12345...
  • References59
  • Citations30
123
/papers/methylation-sensitive-expression-of-a-dna/25826366