Methylation Statuses of H19DMR and KvDMR at WT2 in Wilms Tumors in Taiwan.

Pathology Oncology Research : POR
Meng-Yao LuYen-Chein Lai

Abstract

Wilms tumor is the most common pediatric renal malignancy. Several genetic loci have been shown to be associated with its formation. Genetic or epigenetic aberrations at WT1 and WT2 loci have been implicated in the etiology of the majority of sporadic Wilms tumors. In our previous study, most Wilms tumors tested negative for both constitutional mutations and somatic mutations in the WT1 gene. Thus, WT2 may play an important role in these tumors. In the present study, we analyzed the methylation statuses of WT2 at 11p15 using methylation sensitive multiplex ligation-dependent probe amplification in six Wilms tumors. Paternal uniparental disomy at WT2 was observed in two Wilms tumors with epithelial components due to hypermethylation at H19DMR and hypomethylation at KvDMR. Our findings highlight the benefits of testing for 11p15 epigenetic abnormalities to identify Wilms tumors with epithelial components.

References

Jan 30, 2003·Human Molecular Genetics·Debora Mancini-DiNardoShirley M Tilghman
Feb 28, 2004·Expert Reviews in Molecular Medicine·K W Brown, K T Malik
Aug 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Guido PastoreEva Steliarova-Foucher
Jun 29, 2010·Pediatric Blood & Cancer·Arnauld C VerschuurBengt Sandstedt
Dec 22, 2010·Oncology Reports·Jochen HubertusRoland Kappler
Apr 4, 2012·Oncotarget·Richard H ScottNazneen Rahman
Dec 29, 2012·Genetics and Molecular Biology·Leila C A CardosoFernando R Vargas
Apr 10, 2014·Advances in Anatomic Pathology·Turki Al-HussainMohammed Akhtar
Apr 16, 2017·The Lancet Oncology·Eva Steliarova-FoucherUNKNOWN IICC-3 contributors
Jan 24, 2019·Pathology Oncology Research : POR·Ming-Ru ChiangYen-Chein Lai
Feb 2, 2019·Nature Reviews. Nephrology·Taryn Dora TregerSam Behjati
Mar 20, 2019·The Lancet Child & Adolescent Health·Shazia MahamdallieNazneen Rahman

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Methods Mentioned

BETA
electrophoresis
Profiler
chromosomal aberrations

Software Mentioned

GeneMarker

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