Methylchloroisothiazolinone/methylisothiazolinone contact sensitization: diverging trends in subgroups of IVDK patients in a period of 19 years

Contact Dermatitis
W UterAxel Schnuch

Abstract

The preservative methylchloroisothiazolinone (MCI)/methylisothiazo- linone (MI) is an important allergen, and has thus been subject to regulation in some areas of exposure, mainly in cosmetics. To examine whether a decline in sensitization prevalence and intensity of elicitation (by the patch test) can be observed, either overall, or in certain subgroups defined by causative exposures. On the basis of long-term contact allergy surveillance data collected by the Information Network of Departments of Dermatology (www.ivkd.org), 1992-2010, in the course of 171 883 consultations, the time trend of (different grades of) positive patch test reactions to MCI/MI (0.01% aqua) was examined in an age-stratified analysis. The overall frequency of positive patch test reactions was 2.33% (95% confidence interval 2.26-2.4%). No significant overall trend of positive reactions or of the distribution of +, ++ and + + + reactions (p > 0.05) was observed, similarly to what was found for patients in whom cosmetics were recorded as causative exposure (p = 0.55). In contrast, in patients with occupational contact dermatitis who were < 40 years of age, a significant increase in prevalence, by 0.87 percentage points per decade, was identified (p = 0.01...Continue Reading

References

Jun 29, 2005·Contact Dermatitis·Mari-Ann Flyvholm
Mar 9, 2007·Contact Dermatitis·Jacob Pontoppidan ThyssenTorkil Menné
Aug 10, 2010·Contact Dermatitis·Michael D LundovJeanne D Johansen
Feb 22, 2011·The British Journal of Dermatology·A SchnuchW Uter

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Citations

Jan 18, 2013·Current Opinion in Allergy and Clinical Immunology·Dorothy Linn Holness
Sep 17, 2013·Annales de dermatologie et de vénéréologie·A SchoefflerA Barbaud
Feb 5, 2016·Current Opinion in Allergy and Clinical Immunology·Susan J StocksSarah F Berk
Mar 21, 2013·Contact Dermatitis·Rachel Urwin, Mark Wilkinson
Jul 2, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Vera MahlerAxel Schnuch
May 23, 2014·Contact Dermatitis·Ulrik Fischer FriisJeanne Duus Johansen
Aug 20, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M WormA Schnuch
Jun 19, 2015·Contact Dermatitis·Anna-Reetta VauhkalaKristiina Aalto-Korte
Aug 27, 2015·Current Opinion in Allergy and Clinical Immunology·Faheem Latheef, Stephen Mark Wilkinson
Jan 21, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·N Gäbelein-WissingS C Hofmann
Jan 13, 2015·Dermatitis : Contact, Atopic, Occupational, Drug·Danit Maor, Rosemary Nixon
Nov 8, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E Garcia-HidalgoK Hungerbühler
Jan 31, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A DusefanteF Larese Filon
Jun 14, 2013·Journal of Lower Genital Tract Disease·Caitlyn A FooteMary Gail Mercurio
Aug 6, 2016·Alternatives to Laboratory Animals : ATLA·Maria LeontaridouRobert Landsiedel
Feb 16, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Susann ForkelTimo Buhl

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