Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin

European Journal of Pharmacology
T J ConnorJ P Kelly

Abstract

The purpose of the present study was to examine the role of serotonin release in methylenedioxymethamphetamine (MDMA)-induced immunosuppression in rats. We examined the effect of pretreatment with the selective serotonin reuptake inhibitor paroxetine, and the tryptophan hydroxylase inhibitor para-chlorophenylalanine on MDMA-induced suppression of interleukin-1beta and tumour necrosis factor (TNF)-alpha secretion following an in vivo lipopolysaccharide challenge. Although paroxetine blocked MDMA-induced serotonin depletion in the cortex and hypothalamus, it failed to alter the suppressive effect of MDMA on lipopolysaccharide-induced TNF-alpha secretion. Similarly, although para-chlorophenylalanine caused a 90% depletion in cortical and hypothalamic serotonin content, it failed to alter the suppressive effect of MDMA on lipopolysaccharide-induced interleukin-1beta or TNF-alpha secretion. In conclusion, although MDMA is a potent releaser of serotonin, the suppressive effects of MDMA on lipopolysaccharide-induced proinflammatory cytokine secretion cannot be attributed to its serotonin-releasing properties.

References

Sep 1, 1992·Brain, Behavior, and Immunity·M A PezzoneB S Rabin
Jan 1, 1991·Life Sciences·M Freire-GarabalA Belmonte
Sep 1, 1994·Leukemia & Lymphoma·S KobayashiH Mizoguchi
Oct 1, 1994·Journal of Interferon Research·C A Dinarello
Mar 1, 1993·British Journal of Rheumatology·G W Duff
Jan 1, 1997·Journal of Neural Transmission·S Koch, M P Galloway
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·K M HegadorenM Bourin
Sep 25, 1999·European Journal of Pharmacology·T J ConnorB E Leonard
Mar 10, 2000·European Journal of Pharmacology·J F CryanB E Leonard
Nov 4, 2000·Pediatric Emergency Care·M Shannon

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Citations

Jul 20, 2002·Current Opinion in Pharmacology·Judith Szelényi, Zsolt Selmeczy
Aug 12, 2003·Trends in Immunology·John Gordon, Nicholas M Barnes
May 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara L F KaplanPeer W F Karmaus
Feb 23, 2010·Pharmacology, Biochemistry, and Behavior·Güner UlakB Faruk Erden
Aug 20, 2010·British Journal of Pharmacology·Noreen T Boyle, Thomas J Connor
Jan 29, 2010·Immunopharmacology and Immunotoxicology·Jorge CamarasaElena Escubedo
Aug 31, 2004·The Journal of Pharmacology and Experimental Therapeutics·David A SlatteryJohn F Cryan

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