Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes

Acta Neurologica Scandinavica
T P They-TheyI Slassi

Abstract

The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial. This first case-control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion. We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59-2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke (n = 42); odds ratio, 2.1; 95% CI: 1.17-3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI: 1.86-23.1, P = 0.003, for TT genotype variant compared with CC wild genotype. We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco.

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Oct 4, 1995·JAMA : the Journal of the American Medical Association·C J BousheyA G Motulsky
Jul 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·D E WilckenR M McCredie
Sep 2, 1999·Stroke; a Journal of Cerebral Circulation·Y NotsuS Kobayashi
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Pasquale MadonnaGiovanni Di Minno
Jan 31, 2004·American Journal of Hypertension·Speranza RubattuMassimo Volpe
Apr 29, 2004·American Journal of Hematology·Fahri UçarAlper Pakdemir
Feb 5, 2005·Stroke; a Journal of Cerebral Circulation·Alessandro PezziniAlessandro Padovani
Jun 11, 2005·Stroke; a Journal of Cerebral Circulation·Simon CroninPeter J Kelly
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ryuichi KawamotoTetsuro Miki
Dec 19, 2007·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Sep 1, 2009·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Wassim Y AlmawiMoiz Bakhiet

❮ Previous
Next ❯

Citations

Oct 18, 2013·Neuroscience Bulletin·Thierry Paluku They-TheySellama Nadifi
Jan 19, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yanli SongGaifen Liu
Aug 12, 2014·Cell Biochemistry and Biophysics·Wei ZhangGuorong Bi
Jan 1, 2020·BMC Neurology·Ahmed KharbachRachid Razine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.