Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Patricia CantoRamón Coral-Vázquez

Abstract

Preeclampsia, a common complication of pregnancy, is characterized by elevated blood pressure and proteinuria developing after 20 weeks' gestational age. Susceptibility to this syndrome is believed to have a genetic component. The aim of this study was to investigate whether or not the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T and glutathione S-transferase P1 (GSTP1) A313G polymorphisms are associated with preeclampsia in Maya-Mestizo women. A case-control study was performed, in which 125 preeclamptic patients and 274 healthy controls were genotyped for the MTHFR C677T and GSTP1 A313G polymorphisms by real-time PCR allelic discrimination. Allele and genotype frequencies were compared using the chi2 tests. The MTHFR 677T allele and the 677TT genotype were significantly more frequent in the controls, suggesting an association with a decreased risk of preeclampsia (p = 0.017 and p = 0.007, respectively). Similarly, GSTP1 313GG/GC genotypes and the G allele were more frequent in controls, showing a significant association with reduced risk of preeclampsia (p = 0.008 and p = 0.013, respectively). Our results suggest, for the first time, that the MTHFR 677T and GSTP1 313G polymorphisms confer a significantly decreased r...Continue Reading

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Citations

Sep 28, 2012·Genetic Testing and Molecular Biomarkers·Elith Yazmin Valencia VillalvazoPatricia Canto
Aug 25, 2012·Journal of Thrombosis and Thrombolysis·Lovejeet KaurKallur Nava Saraswathy
Jan 10, 2013·Human Reproduction Update·A J BuurmaH J Baelde
Mar 13, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Peter ChedrauiTommaso Simoncini
Jun 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Peter ChedrauiAntonio W D Gavilanes
Oct 28, 2014·Annals of Human Biology·Thelma Canto-CetinaPatricia Canto
Mar 12, 2015·Journal of Assisted Reproduction and Genetics·Xiaoming WuWenru Tang
Dec 7, 2014·Archives of Gynecology and Obstetrics·Saeedeh SalimiFarzaneh Farajian-Mashhadi
Mar 25, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Paula J Williams, Fiona Broughton Pipkin
Jul 28, 2016·Experimental and Molecular Pathology·Rosa Lilia Esteban-MartínezRamón Mauricio Coral-Vazquez
May 2, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Telmo H Barbosa de LimaSilvia Daher
Jun 11, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Attila MolvarecJános Rigó
Jul 15, 2009·Genetic Testing and Molecular Biomarkers·Arman HaghighatgooDaniel Darvish
May 30, 2015·Circulation. Cardiovascular Genetics·Juan Carlos Pérez-RazoRamón M Coral-Vázquez
Aug 24, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiao-ping XiaYun-xia Cao
May 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Cheng-Juan Sun, Wei-Yuan Zhang
May 30, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Attila MolvarecJános Rigó
Aug 28, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jingyuan HouLiubing Lan
Feb 7, 2019·The Pharmacogenomics Journal·Santiago CuevasPedro A Jose
Oct 21, 2018·Reproductive Biology and Endocrinology : RB&E·Gabriela García-JiménezAlfredo Ulloa-Aguirre
Feb 6, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Sumia F AhmedIshag Adam
Jan 9, 2019·Frontiers in Physiology·Rafael Tomoya MichitaJosé Artur Bogo Chies

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