Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women

European Journal of Endocrinology
Irene LambrinoudakiE Kouskouni

Abstract

To assess the association of genetic polymorphisms related to cardiovascular disease (CVD) risk with anthropometric parameters and indices of androgenicity in healthy postmenopausal women. Cross-sectional study in a University Menopause Clinic. The following polymorphisms were assessed in 84 healthy postmenopausal women: glycoprotein IIIa Leu33Pro, apolipoprotein E2/E3/E4, methylenetetrahydrofolate reductase (MTHFR) Ala222Val, apolipoprotein B Arg3500Gln, paraoxonase 1 Gln192Arg, plasminogen activator inhibitor 1 4G/5G, cholesterol-7 alpha-hydroxylase A-204C, and cholesterol ester transfer protein (TaqIB) B1/B2. Hormonal assays included FSH, LH, 17-beta-estradiol, testosterone, sex hormone-binding globulin (SHBG), DHEA sulfate, Delta-4-androstenedione (Delta4A), free androgen index (FAI), free estrogen index (FEI), and homocysteine (Hcy). The anthropometric components were body mass index (BMI) and waist-to-hip ratio (WHR). MTHFR Ala222Val polymorphism was positively associated with testosterone, FAI, and FEI (P=0.001, P=0.0004, and P=0.014 respectively) and negatively with SHBG (P=0.047). Furthermore, women bearing this polymorphism had higher BMI and WHR compared with women with the wild-type variant (P=0.027 and P=0.044 resp...Continue Reading

Citations

Nov 14, 2012·Climacteric : the Journal of the International Menopause Society·I LambrinoudakiE Kouskouni
Nov 30, 2014·Journal of Translational Medicine·Laura Di RenzoAntonino De Lorenzo
Oct 5, 2010·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Szilvia BokorUNKNOWN Helena Study Group
Jan 8, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karen D CorbinSteven H Zeisel
Nov 21, 2013·Experimental and Therapeutic Medicine·Hyun YangEui-Bae Jeung
May 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sara R ZwartScott M Smith
Sep 10, 2019·Journal of Medical Biochemistry·Evelia Leal-UgarteJosé Ramón Lara-Ramos

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