Methylenetetrahydrofolate reductase C677T polymorphism in Iraqi patients with ischemic stroke

Neurology India
Nasir A S Al-AllawiJaladet M S Jubrael

Abstract

Data are conflicting concerning the association between ischemic stroke and methylenetetrahydrofolate reductase (MTHFR) C677T mutation. Studies addressing this matter in developing countries are limited. This study was undertaken to evaluate MTHFR C677T gene polymorphism as a possible risk factor in patients with ischemic stroke in Iraq. A case-control study in a major teaching hospital in Northern Iraq. Study population included 70 patients with ischemic stroke diagnosed by computed tomography (CT) or magnetic resonance imaging (MRI) and 50 controls matched by age and sex. All the patients and controls had detailed neurologic examination and blood sugar, lipid profile, total homocysteine, as well as, MTHFR gene analysis. The MTHFR C677T mutation status was detected in the amplified products using reverse hybridization to specific mutant and wild oligonucleotide probes by a colorimetric microwell plate method. Mann-Whitney U test and Chi-square tests were used to find the significance. The median age of the patients was 60 years and 54% were males. The MTHFR C677T gene analysis detected TT genotype in 20% of patients and in 6% of controls and CC genotype in 37% of the patients and in 54% of the controls. The calculated risk of ...Continue Reading

Citations

Mar 13, 2012·Neurology India·Baoqiong LiuQidong Yang
May 7, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Najiba Fekih-MrissaRidha Mrissa
Jan 19, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yanli SongGaifen Liu
Sep 7, 2017·Chinese Medical Journal·Yu-Heng ChenPing Zhao
Oct 25, 2017·Indian Journal of Clinical Biochemistry : IJCB·Upendra YadavVandana Rai
Jan 1, 2013·World Journal of Emergency Medicine·Suber DikiciGuven Arslan

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