Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis

Clinical Genetics
Elias Zintzaras

Abstract

The methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been linked to the risk of developing breast cancer. A meta-analysis of 18 case-control studies investigating the association between the C677T and the A1298C polymorphisms of the MTHFR gene and breast cancer (BC) was carried out. The meta-analysis included genotype data on 5467/7336 and 3768/5276 cases/controls for C677T and A1298C, respectively. In the meta-analysis, the consistency of genetic effects across different ethnicities and the effect of menopausal status for various genetic contrasts were investigated. The overall analysis for investigating the association between the C677T allele T and the risk of developing BC showed significant heterogeneity (p = 0.08, I2 = 34%) and non-significant association [odds ratio (OR) 1.02; 95% confidence interval (0.95-1.10)]. The allele contrast was not significant in Caucasians (nine studies) and in East Asians (four studies) [OR 1.03 (0.93-1.14) and OR 0.96 (0.81-1.15), respectively] or in pre-menopausal (five studies) and post-menopausal (four studies) groups [OR 1.10 (0.94-1.29) and OR 1.06 (0.95-1.18), respectively]. The genotype contrast of the homozygotes (TT vs CC) produced significant results only for pre...Continue Reading

References

Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·B C BlountB N Ames
Apr 3, 2001·Trends in Pharmacological Sciences·P M UelandS E Vollset
Nov 22, 2001·JAMA : the Journal of the American Medical Association·K W Singletary, S M Gapstur
Sep 11, 2002·The Journal of Nutrition·Silvina F ChoumenkovitchPaul F Jacques
Dec 11, 2002·Breast Cancer Research : BCR·Ian G CampbellDavid Y H Choong
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 24, 2003·Breast Cancer Research and Treatment·Uwe LangsenlehnerHellmut Samonigg
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Martha J ShrubsoleWei Zheng
Mar 9, 2004·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Emel ErgulN Zafer Canturk
Apr 15, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G Pöschl, H K Seitz
May 7, 2004·Current Opinion in Obstetrics & Gynecology·Shumin M Zhang
May 20, 2004·Experimental & Molecular Medicine·Sang-Ah LeeDong-Young Noh
Sep 16, 2004·Journal of Human Genetics·Elias Zintzaras, Georgios M Hadjigeorgiou
Nov 16, 2004·Nature Genetics·John P A IoannidisThomas A Trikalinos
Feb 1, 2005·Journal of Human Genetics·Elias Zintzaras, Ioannis Stefanidis
Mar 1, 2005·Cancer Research·Jia ChenRegina M Santella
Mar 24, 2005·Journal of Cellular and Molecular Medicine·R G Dumitrescu, I Cotarla
Jun 16, 2005·Bioinformatics·Elias Zintzaras, John P A Ioannidis
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elias ZintzarasFrancesc Vidal

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Citations

Dec 12, 2007·Journal of Human Genetics·Elias Zintzaras, Joseph Lau
Mar 20, 2008·Journal of Human Genetics·Elias ZintzarasMichael Voulgarelis
Apr 25, 2007·Breast Cancer Research and Treatment·Tanja LangsenlehnerUwe Langsenlehner
Jan 22, 2008·Breast Cancer Research and Treatment·Joanne KotsopoulosSteven A Narod
May 21, 2013·Cancer Causes & Control : CCC·Julie K BassettGraham G Giles
Jun 27, 2009·Journal of Human Genetics·Chang-Ming GaoKazuo Tajima
Oct 5, 2006·Journal of the National Cancer Institute·John P A Ioannidis
Jan 5, 2007·Journal of the National Cancer Institute·Susanna C LarssonAlicja Wolk
Jan 30, 2009·Pigment Cell & Melanoma Research·Stanca A BirleaRichard A Spritz
Aug 27, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary E PlatekJo L Freudenheim
Aug 18, 2009·Journal of Experimental & Clinical Cancer Research : CR·Wenlei ZhuoZhengtang Chen
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wei WangDouglas A Keszler
Oct 27, 2006·Nutrition Reviews·Young-In Kim
May 14, 2009·American Journal of Epidemiology·Elias Zintzaras, Nikos Zdoukopoulos
Jul 8, 2009·The Pharmacogenomics Journal·D F CarrUNKNOWN FolATED study team
Jan 21, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Elias Zintzaras
Apr 21, 2009·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xinran Xu, Jia Chen
Dec 11, 2007·Cancer Genetics and Cytogenetics·Yuichi MarutaYuji Hinoda
Jul 7, 2007·Toxicology Letters·Ilse DecordierMicheline Kirsch-Volders
May 1, 2016·Journal of Genetic Counseling·Brooke Levenseller Levin, Elizabeth Varga
Aug 31, 2006·Hypertension·Elias ZintzarasIoannis Stefanidis

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