Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in 9-year-old children.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
C D SteerJon H Tobias

Abstract

The C677T MTHFR polymorphism has been associated with lumbar spine and hip BMD. In older adults, the genetic effect has been reported in women only. However, in younger adults, this influence may only be present in men. This study is the first to investigate associations between the C677T MTHFR polymorphism and bone phenotypes in children. Regression analyses were used to study the relationship between MTHFR genotype and bone phenotypes derived from total body DXA scans in children 9.9 yr of age from the Avon Longitudinal Study of Parents and Children (ALSPAC). A total of 5816 children had both genetic and DXA data for the total body less head region (TBLH) and 3196 for the spine. A strong association was observed between the C677T MTHFR genotype and spine BMD (p < 0.001; 0.10 SD decrease per T allele). There was some evidence that this genetic effect was stronger in boys compared with girls (p = 0.04 for sex interaction). In contrast, there was no association between the C677T MTHFR genotype and TBLH BMD. The association between MTHFR genotype and spine BMD was attenuated particularly in girls by high maternal dietary intakes of vitamin B(6) and folate during pregnancy but not by child dietary intakes at 7 yr. To the extent th...Continue Reading

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Citations

Apr 2, 2010·Endocrine Reviews·Xiang-Hong XuHong-Wen Deng
Feb 15, 2012·The Journal of Spinal Cord Medicine·Humberto MarreirosEulalia Calado
Jul 13, 2013·Current Osteoporosis Reports·Cheryl L Ackert-Bicknell, David Karasik
Mar 21, 2012·PloS One·Caroline L ReltonGeorge Davey Smith
Jul 26, 2016·Experimental and Therapeutic Medicine·Nataša Karas-KuželičkiIrena Mlinarič-Raščan
Apr 29, 2011·The American Journal of Clinical Nutrition·Colin D Steer, Jonathan H Tobias

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