Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service

Italian Journal of Pediatrics
A OrsiniD G Peroni

Abstract

In adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children. A retrospective study of children referred with headache to a tertiary level Paediatric Neurology Service between 2008 and 2012. This study included only patients who had been genotyped for the MTHFR C677T polymorphism. An evaluation of homocysteine serum levels was necessary to exclude other types of migraine. Compared with the wild-type genotype, the T/T genotype was associated with an increased risk of any type of migraine, though the statistical significance was greatest in migraine with aura. The homocysteine serum levels were significantly higher in migraine with aura compared to migraine without aura. In a pediatric population MTHFR T/T homozygosity influences susceptibility to migraine.

References

May 12, 2006·Cephalalgia : an International Journal of Headache·F BottiniA C Molinari
Jun 6, 2012·Hematology·M FerraraR Russo
Dec 12, 2012·Cephalalgia : an International Journal of Headache·Ann I ScherLenore J Launer
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)
Sep 26, 2013·The Journal of Headache and Pain·Benedetta BelliniVincenzo Guidetti
Nov 5, 2013·Journal of the Neurological Sciences·Ruozhuo LiuWei Zhang
Feb 11, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sukhvinder KaurBalkirat Singh

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Citations

Jan 16, 2021·Journal of Molecular Neuroscience : MN·Kaveh EbahimzadehSoudeh Ghafouri-Fard

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

JMP

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