Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls

Breast Cancer Research and Treatment
Xiaowei QiJun Jiang

Abstract

The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk has been widely reported, but results were inconsistent and underpowered. To clarify the effects of MTHFR polymorphisms on the risk of breast cancer, an updated meta-analysis of all available studies relating C677T and/or A1298C polymorphisms of MTHFR gene to the risk of breast cancer was conducted. Eligible articles were identified by search of databases including MEDLINE, PubMed, Web of Science, EMBASE and Chinese Biomedical Literature database (CBM) for the period up to January 2010. Finally, a total of 41 studies with 16,480 cases and 22,388 controls were included, all for C677T polymorphism and 20 with 12,170 cases and 15,865 controls for A1298C polymorphism. The pooled ORs were performed for the allele contrasts, additive genetic model, dominant genetic model, and recessive genetic model, respectively. Subgroup analyses were also performed by ethnicity and menopausal status. With respect to C677T polymorphism, significantly elevated breast cancer risk was found in overall analysis (T vs. C: OR = 1.041, 95% CI = 1.009-1.073; TT vs. CC: OR = 1.132, 95% CI = 1.019-1.259; TT vs. CC + CT: OR = 1.119, 95% CI = 1.014-1.2...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jul 29, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P GoyetteR Rozen
Aug 16, 2002·American Journal of Epidemiology·Julian LittleClarice Weinberg
Dec 11, 2002·Breast Cancer Research : BCR·Ian G CampbellDavid Y H Choong
Feb 27, 2003·Breast Cancer Research and Treatment·Jan C SemenzaHoda Anton-Culver
Oct 24, 2003·Breast Cancer Research and Treatment·Uwe LangsenlehnerHellmut Samonigg
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Martha J ShrubsoleWei Zheng
Mar 9, 2004·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Emel ErgulN Zafer Canturk
May 20, 2004·Experimental & Molecular Medicine·Sang-Ah LeeDong-Young Noh
Mar 1, 2005·Cancer Research·Jia ChenRegina M Santella
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Sep 1, 2005·Cell Biochemistry and Function·Nezih HekimTurgay Isbir
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christina JustenhovenHiltrud Brauch
Jun 30, 2006·Contemporary Clinical Trials·Rebecca DerSimonian, Raghu Kacker
Jan 5, 2007·Journal of the National Cancer Institute·Susanna C LarssonAlicja Wolk
Feb 22, 2007·International Journal of Cancer. Journal International Du Cancer·Jolanta LissowskaMontserrat Garcia-Closas
Apr 25, 2007·Breast Cancer Research and Treatment·Tanja LangsenlehnerUwe Langsenlehner
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Victoria L StevensEugenia E Calle
Sep 27, 2007·Breast Cancer Research and Treatment·Chun-Wen ChengChen-Yang Shen
Jan 5, 2008·Carcinogenesis·Takeshi SuzukiKazuo Tajima
Jan 22, 2008·Breast Cancer Research and Treatment·Joanne KotsopoulosSteven A Narod
Jan 16, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elena De Mattia, Giuseppe Toffoli
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Meng Hua TaoJo L Freudenheim
Apr 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ulrika EricsonElisabet Wirfält
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 27, 2009·Journal of Human Genetics·Chang-Ming GaoKazuo Tajima
Jul 25, 2009·Breast Cancer Research and Treatment·Theodoros N Sergentanis, Konstantinos P Economopoulos
Aug 27, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary E PlatekJo L Freudenheim
Aug 27, 2009·European Journal of Clinical Nutrition·A R BentleyP A Cassano
Sep 18, 2009·The American Journal of Clinical Nutrition·Ulrika C EricsonElisabet Wirfält
Nov 4, 2009·Oncology Reports·L A Henríquez-HernándezL Fernández Pérez
Dec 2, 2009·Breast Cancer Research and Treatment·Zhanwei WangWen-ming Chu

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Citations

Apr 23, 2010·Breast Cancer Research and Treatment·Jia HuYa-Jie Wang
May 15, 2010·Breast Cancer Research and Treatment·Aydan Eroğlu, Nejat Akar
Mar 1, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bassam LajinAmal Alachkar
Jan 5, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Scott E HickeyHelga V Toriello
Jun 7, 2012·British Journal of Cancer·A JakubowskaUNKNOWN CIMBA, the Consortium of Investigators of Modifiers of BRCA1/2-Related Cancer
Jan 20, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tian-Xin XiangXiao-Ping Wu
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Filiz OzenOzturk Ozdemir
May 1, 2016·Journal of Genetic Counseling·Brooke Levenseller Levin, Elizabeth Varga
Oct 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jing NiQiang Wu
Dec 3, 2011·Molecular Biology Reports·Rita de Cássia Carvalho BarbosaSilvia Helena Barem Rabenhorst
Sep 29, 2018·Global Health, Epidemiology and Genomics·A AbbadF Radouani
Sep 1, 2016·Personalized Medicine·Shantanu GirotraOlga Golubnitschaja
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Meriem SlaouiMariam Amrani
May 26, 2017·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Hanieh RezaeiFahimeh Nemati Mansur
Jan 7, 2020·Journal of Nutritional Science and Vitaminology·Xiang ChenChunXin Wang
May 11, 2011·Molecular Biology Reports·Ana Lívia Silva GalbiattiEny Maria Goloni-Bertollo
Jan 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Moniek van ZitterenA Cecile J W Janssens

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