Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation

Amino Acids
Fernanda HansenCarlos-Alberto Gonçalves

Abstract

Diabetes is a metabolic disease characterized by high fasting-glucose levels. Diabetic complications have been associated with hyperglycemia and high levels of reactive compounds, such as methylglyoxal (MG) and advanced glycation endproducts (AGEs) formation derived from glucose. Diabetic patients have a higher risk of developing neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. Herein, we examined the effect of high glucose, MG and carboxyethyllysine (CEL), a MG-derived AGE of lysine, on oxidative, metabolic and astrocyte-specific parameters in acute hippocampal slices, and investigated some of the mechanisms that could mediate these effects. Glucose, MG and CEL did not alter reactive oxygen species (ROS) formation, glucose uptake or glutamine synthetase activity. However, glutamate uptake and S100B secretion were decreased after MG and CEL exposure. RAGE activation and glycation reactions, examined by aminoguanidine and L-lysine co-incubation, did not mediate these changes. Acute MG and CEL exposure, but not glucose, were able to induce similar effects on hippocampal slices, suggesting that conditions of high glucose concentrations are primarily toxic by elevating the rates of these glycation com...Continue Reading

References

Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Jan 1, 1993·Molecular Aspects of Medicine·P J Thornalley
Mar 12, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·R MinetL Cynober
Jan 19, 1999·Diabetes·P J BeisswengerB S Szwergold
Jan 5, 2002·Diabetes/metabolism Research and Reviews·H Vlassara
Mar 23, 2002·Journal of Neurochemistry·F GardoniM Di Luca
Nov 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Annunziata LapollaPietro Traldi
Jul 13, 2004·Mechanisms of Ageing and Development·Ana Paula ThomaziSusana T Wofchuk
Nov 16, 2004·Trends in Neurosciences·Leif Hertz, H Ronald Zielke
Apr 13, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Motoko KawaguchiMakio Kobayashi
Jul 19, 2005·Nature Reviews. Neuroscience·Andrea Volterra, Jacopo Meldolesi
Jul 23, 2005·Annals of the New York Academy of Sciences·Paul J Thornalley
Sep 10, 2005·Current Opinion in Neurobiology·Sreedharan SajikumarJulietta Uta Frey
Mar 8, 2006·Free Radical Biology & Medicine·Susana Garcia de ArribaClemens Allgaier
Jun 24, 2006·Neurochemical Research·Francine TramontinaCarlos-Alberto Gonçalves
Sep 19, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·A S A KhanA B Ahmed
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Jan AlbrechtArne Schousboe
Mar 14, 2007·Neurochemistry International·Patrícia NardinCarlos-Alberto Gonçalves
Sep 18, 2007·The International Journal of Biochemistry & Cell Biology·Silvia Di LoretoFernanda Amicarelli
Jan 8, 2008·Journal of Neuroscience Methods·Marina Concli LeiteCarlos-Alberto Gonçalves
Nov 18, 2008·Journal of Neurochemistry·Hyun Kyoung LeeHwan Tae Park
Dec 27, 2008·Biochimica Et Biophysica Acta·Rosario DonatoIleana Giambanco
Mar 17, 2009·Neurochemical Research·Patrícia NardinCarlos-Alberto Gonçalves
Dec 31, 2009·European Archives of Psychiatry and Clinical Neuroscience·André Quincozes-SantosCarmem Gottfried
Jan 26, 2011·Nature Reviews. Endocrinology·Mark W J StrachanJacqueline F Price
Feb 10, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Johann SteinerHans-Gert Bernstein
Mar 8, 2011·Diabetes Care·Qun XuHonglei Chen
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mireille BélangerIgor Allaman
Nov 21, 2013·Diabetes Care·Joshua I BarzilayUNKNOWN TINSAL-T2D Research Consortium
Nov 26, 2013·Glia·Takahiro TakanoMaiken Nedergaard
Dec 21, 2013·Diabetes·Naila Rabbani, Paul J Thornalley

❮ Previous
Next ❯

Citations

Apr 17, 2016·Neurochemical Research·Patrícia NardinCarlos-Alberto Gonçalves
Nov 6, 2018·Neurochemical Research·Adriana Fernanda K VizueteCarlos-Alberto Gonçalves
Apr 12, 2017·Brain : a Journal of Neurology·Hugo Vicente MirandaTiago F Outeiro
Jul 8, 2017·Oxidative Medicine and Cellular Longevity·Fernanda HansenCarlos-Alberto Gonçalves
Nov 20, 2016·Scientific Reports·Hugo Vicente MirandaTiago Fleming Outeiro
Aug 27, 2018·Molecular Neurobiology·Caroline ZanottoCarlos-Alberto Gonçalves
Feb 8, 2019·Frontiers in Neuroscience·Carlos-Alberto GonçalvesMarina C Leite

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Related Papers

Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
Mario Cárdenas-LeónFernando Larrea
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
M AbelE Ritz
© 2021 Meta ULC. All rights reserved