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Methylglyoxal and Glyoxal as Potential Peripheral Markers for MCI Diagnosis and Their Effects on the Expression of Neurotrophic, Inflammatory and Neurodegenerative Factors in Neurons and in Neuronal Derived-Extracellular Vesicles

International Journal of Molecular Sciences

Oct 3, 2019

Mohamed HaddadCharles Ramassamy

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Abstract

Methylglyoxal (MG) and glyoxal (GO) are suggested to be associated with the development of neurodegenerative pathologies. However, their peripheral levels in relation to cognitive decline and their effects on key factors in neuronal cells are poorly investigated. The aim of this study w...read more

Mentioned in this Paper

Alzheimer's Disease
High Pressure Liquid Chromatography Procedure
Genetic Markers
Glyoxal
Neurons
Pyruvaldehyde
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Receptor for advanced glycation endproducts
Brain-Derived Neurotrophic Factor
1
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Methylglyoxal and Glyoxal as Potential Peripheral Markers for MCI Diagnosis and Their Effects on the Expression of Neurotrophic, Inflammatory and Neurodegenerative Factors in Neurons and in Neuronal Derived-Extracellular Vesicles

International Journal of Molecular Sciences

Oct 3, 2019

Mohamed HaddadCharles Ramassamy

PMID: 31623327

DOI: 10.3390/ijms20194906

Abstract

Methylglyoxal (MG) and glyoxal (GO) are suggested to be associated with the development of neurodegenerative pathologies. However, their peripheral levels in relation to cognitive decline and their effects on key factors in neuronal cells are poorly investigated. The aim of this study w...read more

Mentioned in this Paper

Alzheimer's Disease
High Pressure Liquid Chromatography Procedure
Genetic Markers
Glyoxal
Neurons
1

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