Methylmalonic Acid and Homocysteine as Indicators of Vitamin B12 Deficiency in Patients with Gastric Cancer after Gastrectomy

Nutrients
Sae-Mi LeeSoo-Youn Lee

Abstract

Vitamin B12 deficiency is a common complication in patients after gastrectomy. Elevated methylmalonic acid (MMA) and homocysteine are better indications of vitamin B12 deficiency than vitamin B12 serum level. We compared MMA and homocysteine levels of patients with gastric cancer after gastrectomy (n = 151) with controls (n = 142) and evaluated the prevalence of vitamin B12 deficiency using MMA and homocysteine in patients. MMA and homocysteine levels were significantly higher (p < 0.05) in patients with gastric cancer after gastrectomy. Of the 151 patients assessed after gastrectomy, 32 patients (21.2%) were vitamin B12 deficient as defined by serum MMA levels > 350 nmol/L, and 8 patients (5.3%) were vitamin B12 deficient as defined by serum homocysteine levels > 15 μmol/L. Both MMA and homocysteine levels were elevated in 7 patients. Among 33 patients with elevated MMA or homocysteine levels, 8 patients (24.2%) were vitamin B12 deficient based on a serum vitamin B12 level < 200 pg/mL. Additionally, levels of MMA and homocysteine were compared pre- and post-gastrectomy in 27 patients. The median MMA level was higher in patients with post-gastrectomy compared to pre-gastrectomy, while the median serum homocysteine level was not...Continue Reading

References

Mar 24, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hidenari SakutaKazuo Hase
Mar 17, 2007·Hematology·Cengìz BeyanAlì Ihsan Uzar
Mar 28, 2008·Analytical and Bioanalytical Chemistry·Christel HempenGertjan van der Sluijs Veer
Jan 1, 2009·The American Journal of Clinical Nutrition·Lindsay H Allen
May 1, 2009·The American Journal of Clinical Nutrition·Leane HoeyHelene McNulty
May 20, 2011·The American Journal of Clinical Nutrition·Elizabeth A YetleyMary Frances Picciano
Jun 17, 2011·The American Journal of Clinical Nutrition·Regan L BaileyElizabeth A Yetley
Nov 17, 2012·World Journal of Gastroenterology : WJG·Chul-Hyun LimCho-Hyun Park
Jun 20, 2014·British Journal of Haematology·Vinod DevaliaUNKNOWN British Committee for Standards in Haematology
Sep 6, 2014·BMJ : British Medical Journal·Alesia HuntSusan Robinson
Oct 10, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ahmet BiliciMahmut Gumus
Mar 19, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Chang-Mo OhUNKNOWN Community of Population-Based Regional Cancer Registries

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Citations

Jul 28, 2020·Journal of Clinical Medicine·Sopak SupakulGeoffrey Urbanski
Nov 27, 2020·Nutrición hospitalaria·Javier Blasco-AlonsoGuiomar Gutiérrez Schiaffino
Aug 20, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yang ZhengFang-Xiao Gong
Apr 3, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xiang ShuXiao-Ou Shu

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Methods Mentioned

BETA
blood collection

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