Methylmercury affects cerebrovascular reactivity to angiotensin II and acetylcholine via Rho-kinase and nitric oxide pathways in mice

Life Sciences
Md Zahorul IslamAtsushi Miyamoto

Abstract

Methylmercury (MeHg) exposure results in increased risk of hypertension and cardiovascular diseases. In this study, we aimed to investigate whether the in vivo exposure of MeHg in mice affects blood pressure and basilar arterial responses to angiotensin II (Ang II) and acetylcholine (ACh), which are important modulators of cerebrovascular autoregulation. Mice were exposed to MeHg (40ppm) in drinking water for 21days. Blood pressure was measured in conscious mice by an indirect tail-cuff method. Functional studies of the isolated arteries' response to vasoactive substances were performed using a micro-organ-bath system. Systolic and mean blood pressures were significantly increased after 2 and 3weeks of treatment with MeHg, respectively. Ang II-induced contraction in an isolated basilar artery, which is mediated via Rho-kinase activation, was increased in MeHg-treated mice. ACh-induced relaxation, which is dependent on NO production from the endothelial cells, was decreased in MeHg-treated mice. However, alterations of vascular responses to Ang II and ACh were not observed in the isolated thoracic aorta. This study demonstrated that the cerebral vasculature appears to be particularly sensitive to in vivo exposure of MeHg. Our re...Continue Reading

References

Sep 1, 1995·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M UchinoM Ando
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Mar 8, 2002·Hypertension·Kanchan Chitaley, R Clinton Webb
Nov 2, 2002·Hypertension·Carlene A HamiltonAnna F Dominiczak
Nov 29, 2002·The New England Journal of Medicine·Eliseo GuallarUNKNOWN Heavy Metals and Myocardial Infarction Study Group
May 13, 2003·Environmental Toxicology·Paul B TchounwouDwayne Sutton
Nov 26, 2003·European Journal of Pharmacology·Ayotunde S O AdeagboPaul J Matheson
May 7, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nobuyuki MorikiTakeshi Nakano
Sep 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Liming JinR Clinton Webb
Jan 8, 2005·Stroke; a Journal of Cerebral Circulation·Sean P DidionFrank M Faraci
Aug 12, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Frank M FaraciSean P Didion
Oct 8, 2005·Circulation Research·Alyson A MillerChristopher G Sobey
Dec 13, 2005·Circulation Research·Yoshiyuki Rikitake, James K Liao
Mar 4, 2006·Journal of Applied Physiology·F M FaraciS P Didion
Mar 30, 2006·The Journal of Pharmacology and Experimental Therapeutics·Liming JinR Clinton Webb
Mar 17, 2007·International Journal of Toxicology·Thomas J HageleNarasimham L Parinandi
Apr 24, 2007·Neurotoxicity Research·Carolina JohanssonSandra Ceccatelli
May 17, 2008·Regulatory Toxicology and Pharmacology : RTP·Anna F CastoldiLuigi Manzo
Jul 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·G A WiggersM Salaices
Oct 22, 2008·Trends in Molecular Medicine·Sophocles Chrissobolis, Frank M Faraci
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Alyson A MillerChristopher G Sobey
Apr 2, 2009·Environmental Health Perspectives·Anna L ChoiPhilippe Grandjean
May 24, 2011·Toxicology and Applied Pharmacology·Marcelo FarinaJoão B T Rocha
Aug 21, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eduardo Luiz MoreiraMarcelo Farina
Apr 23, 2013·Journal of Internal Medicine·S CeccatelliS Spulber
Sep 18, 2013·Journal of the American Heart Association·Jintao WangDaniel T Eitzman

❮ Previous
Next ❯

Citations

Feb 16, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Airton da Cunha MartinsFernando Barbosa
Dec 7, 2018·Environmental Science and Pollution Research International·Gema Gallego-ViñasSabrina Llop
Mar 17, 2019·Journal of Molecular Neuroscience : MN·Geir BjørklundJan Aaseth
Nov 3, 2016·The Journal of Veterinary Medical Science·Cuong VAN DaoAtsushi Miyamoto
Aug 14, 2020·Ecotoxicology and Environmental Safety·Paola Caroline Lacerda LeocádioJacqueline I Alvarez-Leite

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.