Methylmercury induces hyaluronan synthesis in cultured human brain microvascular endothelial cells and pericytes via different mechanisms

The Journal of Toxicological Sciences
Takashi HirookaToshiyuki Kaji

Abstract

In a cerebrum damaged by methylmercury, where neuropathological lesions tend to localize along deep sulci and fissures, edematous changes in white matter have been proposed as the cause of such localization. Since hyaluronan has a high water-retention capability and can contribute to the progression of edematous changes, we hypothesize that methylmercury increases hyaluronan in brain microvascular cells. Our experimental results indicate that methylmercury induces the expression of hyaluronan in cultured human microvascular endothelial cells and pericytes through the induction of expressed UDP-glucose dehydrogenase and hyaluronan synthase 2, respectively. After exposure to methylmercury, hyaluronan largely accumulates in perivascular space, where it contributes to the progression of edematous changes.

References

May 30, 1997·The Journal of Biological Chemistry·P H WeigelM Tammi
Jan 23, 1998·Toxicologic Pathology·K Eto
Jul 2, 2003·Neurotoxicity Research·Coral SanfeliuEduard Rodríguez-Farré
Dec 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Takashi HirookaToshiyuki Kaji

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Citations

Aug 19, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Baizhuo DongHongwei Feng
May 19, 2019·International Journal of Molecular Sciences·Tetsuya Takahashi, Takayoshi Shimohata

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