PMID: 11931977Apr 5, 2002Paper

Methylmercury induces the opening of the permeability transition pore in rat liver mitochondria

Journal of Inorganic Biochemistry
Marcantonio BragadinAntonio Toninello

Abstract

Interactions of methylmercury (CH(3)HgCl) with non-energized mitochondria from rat liver (non-respiring mitochondria) have been investigated in this paper. It has been shown that CH(3)HgCl induces swelling in mitochondria suspended in a sucrose medium. Swelling has also been induced by detergent compounds and by phenylarsine, a chemical compound which induces opening of the permeant transition pore (MTP). Opening of the MTP is inhibited by means of cyclosporine A. Results indicate that the swelling induced by CH(3)HgCl, as in the case of phenylarsine, is inhibited by cyclosporine A and Mg(2+), while swelling induced by detergent compounds is not cyclosporine sensitive. This comparison suggests that CH(3)HgCl induces opening of a permeability transition pore (MTP). Since the opening of an MTP induces cell death, this interaction with MTP could be one of the causes of toxicity of CH(3)HgCl.

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Citations

Aug 13, 2015·Archives of Environmental Contamination and Toxicology·Aurélie DupontKrishna Das
Jan 5, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Faida Husein AbdallaMaria Beatriz Moretto
Feb 24, 2016·Scientific Reports·Jin-Yong LeeGi-Wook Hwang
Dec 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel W CaitoMichael Aschner
Mar 21, 2007·Journal of Inorganic Biochemistry·Marcantonio BragadinSabrina Manente

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