PMID: 15378990Sep 24, 2004Paper

Methylmercury uptake and distribution kinetics in sheepshead minnows, Cyprinodon variegatus, after exposure to Ch3Hg-spiked food

Environmental Toxicology and Chemistry
Joy J Leaner, Robert P Mason

Abstract

The distribution kinetics of methylmercury (CH3Hg[II]) was determined in sheepshead minnows (Cyprinodon variegatus) after a single dose of different CH3Hg(II)-spiked food to determine what factors influence the bioavailability, uptake, and redistribution of CH3Hg(II) to various organs of C. variegatus. The kinetics of CH3Hg(II) distribution was measured in the different organs during a period of 0.1 to 35 d after dosage. The CH3Hg(II) distribution kinetics in the different tissues was modeled using a simple multicompartmental pharmacokinetic model, which assumed that blood was the conduit linking the CH3Hg(II) exchange between the different organs. The CH3Hg(II) was taken up into the intestinal tissue within hours after feeding, followed by a slow release to the blood and the other organs of the body. Exchange between the blood and the visceral organs was relatively slow, with maximum CH3Hg(II) uptake in the liver and gill occurring at 1.5 d following dietary exposure. Subsequently, the majority of the CH3Hg(II) was channeled from the viscera to the rest of the body with a substantial lag time after feeding. However, the rate of transfer between tissues in the studies reported here were faster than those measured by others for ...Continue Reading

Citations

Aug 24, 2010·Archives of Environmental Contamination and Toxicology·Cláudia Leopoldina MieiroArmando Costa Duarte
Dec 11, 2008·Environmental Monitoring and Assessment·Leanne L StahlJennifer L Pitt
Feb 15, 2011·Environmental Science and Pollution Research International·Chavon R WilliamsJaco M Nel
Jul 11, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Joy J Leaner, Robert P Mason
Apr 10, 2013·Environmental Science & Technology·Jillian L A Van WalleghemHolger Hintelmann
Jun 12, 2013·Environmental Science & Technology·Rui WangWen-Xiong Wang
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Aug 18, 2021·Toxicology and Applied Pharmacology·Francesca PellicanòSimona Panunzi
Sep 19, 2007·Environmental Science & Technology·Jillian L A Van WalleghemHolger Hintelmann

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