Methylome Patterns of Cattle Adaptation to Heat Stress.

Frontiers in Genetics
Marcello Del CorvoPaolo Ajmone-Marsan

Abstract

Heat stress has a detrimental impact on cattle health, welfare and productivity by affecting gene expression, metabolism and immune response, but little is known on the epigenetic mechanisms mediating the effect of temperature at the cellular and organism level. In this study, we investigated genome-wide DNA methylation in blood samples collected from 5 bulls of the heat stress resilient Nellore breed and 5 bulls of the Angus that are more heat stress susceptible, exposed to the sun and high temperature-high humidity during the summer season of the Brazilian South-East region. The methylomes were analyzed during and after the exposure by Reduced Representation Bisulfite Sequencing, which provided genome-wide single-base resolution methylation profiles. Significant methylation changes between stressful and recovery periods were observed in 819 genes. Among these, 351 were only seen in Angus, 366 were specific to Nellore, and 102 showed significant changes in methylation patterns in both breeds. KEGG and Gene Ontology (GO) enrichment analyses showed that responses were breed-specific. Interestingly, in Nellore significant genes and pathways were mainly involved in stress responses and cellular defense and were under methylated du...Continue Reading

References

Jan 1, 1990·Annual Review of Immunology·H von Boehmer
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·W F XuD C Foster
Jan 19, 2000·Nature·B D Strahl, C D Allis
Mar 13, 2001·Annual Review of Immunology·R S Lewis
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie VergnollePatricia Andrade-Gordon
Aug 3, 2002·Nature Reviews. Immunology·Mitchell Kronenberg, Laurent Gapin
Feb 25, 2003·Journal of Animal Science·T A OlsonA C Hammond
Apr 25, 2003·Trends in Genetics : TIG·Michel GeorgesNoelle Cockett
Oct 24, 2003·Nature·Anne-Sophie Van LaereLeif Andersson
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Thomas Holbro, Nancy E Hynes
Jul 30, 2005·Cardiovascular Research·Ping LiaoTuck Wah Soong
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ngoc P LyT Bernard Kinane
Mar 7, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hai LinJohan Buyse
Sep 6, 2006·Circulation·Andrew J LegerAthan Kuliopulos
Nov 2, 2006·Physiological Genomics·Tony VuocoloRoss L Tellam
Dec 16, 2006·Rheumatology International·Syngliti-Henrietta PelidouAthanassios Kyritsis
Feb 27, 2007·Cell·Aaron D GoldbergEmily Bernstein
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mitchell Kronenberg, Laurent Gapin
Jan 26, 2008·Journal of Dairy Science·R J CollierL H Baumgard
Feb 26, 2008·Cell·Stuart H Orkin, Leonard I Zon
Feb 5, 2010·Journal of Mammary Gland Biology and Neoplasia·Kuljeet SinghKerst Stelwagen
Mar 27, 2010·Journal of Dairy Science·I AguilarS Tsuruta
Apr 16, 2011·Bioinformatics·Felix Krueger, Simon R Andrews
Sep 15, 2011·Multiple Sclerosis : Clinical and Laboratory Research·P HämäläinenJ Ruutiainen
Oct 12, 2011·Ageing Research Reviews·Alexey A MoskalevVadim E Fraifeld
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
May 24, 2012·Nature Communications·Mingzhou LiRuiqiang Li
Sep 25, 2012·Biochimica Et Biophysica Acta·Lisandro LungatoVânia D'Almeida
Nov 22, 2012·Acta Physiologica·T YoshiharaS Katamoto
Feb 9, 2013·Nature Reviews. Immunology·Christoph ScheiermannPaul S Frenette

❮ Previous
Next ❯

Software Mentioned

Trim Galore
Ensembl
Picard Tools
FastQC
R
methylKit
Illumina Casava pipeline
Bismark
bowtie2
clusterProfiler

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.