Methylome profiling of young adults with depression supports a link with immune response and psoriasis.

Clinical Epigenetics
Coral R LapsleyElaine K Murray

Abstract

Currently the leading cause of global disability, clinical depression is a heterogeneous condition characterised by low mood, anhedonia and cognitive impairments. Its growing incidence among young people, often co-occurring with self-harm, is of particular concern. We recently reported very high rates of depression among first year university students in Northern Ireland, with over 25% meeting the clinical criteria, based on DSM IV. However, the causes of depression in such groups remain unclear, and diagnosis is hampered by a lack of biological markers. The aim of this exploratory study was to examine DNA methylation patterns in saliva samples from individuals with a history of depression and matched healthy controls. From our student subjects who showed evidence of a total lifetime major depressive event (MDE, n = 186) we identified a small but distinct subgroup (n = 30) with higher risk scores on the basis of co-occurrence of self-harm and attempted suicide. Factors conferring elevated risk included being female or non-heterosexual, and intrinsic factors such as emotional suppression and impulsiveness. Saliva samples were collected and a closely matched set of high-risk cases (n = 16) and healthy controls (n = 16) similar in...Continue Reading

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Citations

Aug 28, 2021·International Journal of Molecular Sciences·Dorota Purzycka-BohdanRoman J Nowicki

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Methods Mentioned

BETA
chip
PCA
chips
Assay
PCR

Software Mentioned

DNAcopy package
RnBeads
PyroMark Assay Design
EpiDISH
Galaxy
DAVID
RStudio
PyroMark Q24
methylumi
R

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