Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters

Behavioural Pharmacology
Ying-Shan PiaoIchiro Sora

Abstract

Methylone (2-methylamino-1-[3,4-methylenedioxy-phenyl]propan-1-one), an amphetamine analog, has emerged as a popular drug of abuse worldwide. Methylone induces hyperthermia, which is thought to contribute toward the lethal consequences of methylone overdose. Methylone has been assumed to induce hyperthermic effects through inhibition of serotonin and/or dopamine transporters (SERT and DAT, respectively). To examine the roles of each of these proteins in methylone-induced toxic effects, we used SERT and DAT knockout (KO) mice and assessed the hyperthermic and lethal effects caused by a single administration of methylone. Methylone produced higher rates of lethal toxicity compared with other amphetamine analogs in wild-type mice. Compared with wild-type mice, lethality was significantly lower in DAT KO mice, but not in SERT KO mice. By contrast, only a slight diminution in the hyperthermic effects of methylone was observed in DAT KO mice, whereas a slight enhancement of these effects was observed in SERT KO mice. Administration of the selective D1 receptor antagonist SCH 23390 and the D2 receptor antagonist raclopride reduced methylone-induced hyperthermia, but these drugs also had hypothermic effects in saline-treated mice, albe...Continue Reading

References

Oct 8, 1997·Journal of Accident & Emergency Medicine·A Mallick, A R Bodenham
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·T A Dal CasonR A Glennon
Apr 29, 1999·Journal of Neuroscience Research·A H StokesK E Vrana
Aug 23, 2001·Brain Research. Brain Research Reviews·C DavidsonE H Ellinwood
Apr 3, 2003·The American Journal of Emergency Medicine·Shaun L GreeneMary Kerins
Jul 13, 2004·The European Journal of Neuroscience·P Leon Brown, Eugene A Kiyatkin
Jan 11, 2007·Annual Review of Pharmacology and Toxicology·Annette E FleckensteinGlen R Hanson
Jan 16, 2007·European Journal of Pharmacology·Fumiko NagaiKanako Satoh Hisashi Kamimura
Mar 6, 2010·Annals of the New York Academy of Sciences·Ichiro SoraKazutaka Ikeda
Aug 26, 2010·Addiction·Adam R WinstockFabrizio Schifano
Sep 10, 2010·Journal of Psychopharmacology·Tibor M BruntWim van den Brink
Jul 15, 2011·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Cindy Boulanger-GobeilPierre L Auger
Dec 14, 2011·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Brandon J WarrickCynthia Aaron
Apr 19, 2012·British Journal of Pharmacology·Raul López-ArnauJorge Camarasa
Oct 27, 2012·Pharmacology, Biochemistry, and Behavior·Bjørnar den HollanderEsa R Korpi
Apr 16, 2013·Biochemical Pharmacology·Amy J EshlemanAaron Janowsky
Jul 11, 2013·Behavioural Pharmacology·Michael B GatchMichael J Forster
Apr 18, 2014·Basic & Clinical Pharmacology & Toxicology·Louise KarlssonFredrik C Kugelberg

❮ Previous
Next ❯

Citations

Jun 9, 2016·Journal of Neurogenetics·Evgeniya V EfimovaTatyana D Sotnikova
Feb 1, 2017·Journal of Analytical Toxicology·Phoutthasone ThirakulJulia M Pearson
Dec 6, 2017·Frontiers in Psychiatry·Kristýna ŠtefkováTomáš Páleníček

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.