Methylphenidate alters selective attention by amplifying salience

Psychopharmacology
Niels Ter HuurneRoshan Cools

Abstract

Methylphenidate, the most common treatment of attention deficit hyperactivity disorder (ADHD), is increasingly used by healthy individuals as a "smart drug" to enhance cognitive abilities like attention. A key feature of (selective) attention is the ability to ignore irrelevant but salient information in the environment (distractors). Although crucial for cognitive performance, until now, it is not known how the use of methylphenidate affects resistance to attentional capture by distractors. The present study aims to clarify how methylphenidate affects distractor suppression in healthy individuals. The effect of methylphenidate (20 mg) on distractor suppression was assessed in healthy subjects (N = 20), in a within-subject double-blind placebo-controlled crossover design. We used a visuospatial attention task with target faces flanked by strong (faces) or weak distractors (scrambled faces). Methylphenidate increased accuracy on trials that required gender identification of target face stimuli (methylphenidate 88.9 ± 1.4 [mean ± SEM], placebo 86.0 ± 1.2 %; p = .003), suggesting increased processing of the faces. At the same time, however, methylphenidate increased reaction time when the target face was flanked by a face distract...Continue Reading

References

Jan 1, 1990·Annual Review of Neuroscience·M I Posner, S E Petersen
Jan 1, 1995·Annual Review of Neuroscience·R Desimone, J Duncan
Jan 1, 1993·Psychopharmacology·H S Koelega
Apr 24, 1999·Trends in Neurosciences·P RedgraveK Gurney
Feb 28, 2002·Trends in Cognitive Sciences·Christian Keysers, David I. Perrett
Nov 6, 2002·Psychopharmacology·Danielle C TurnerBarbara J Sahakian
Nov 19, 2003·Psychonomic Bulletin & Review·Dominique LamyHoward E Egeth
Nov 13, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Roshan Cools, Trevor W Robbins
Jan 11, 2005·Vision Research·Jochen LaubrockReinhold Kliegl
Jan 11, 2005·Neuroreport·Corentin Jacques, Bruno Rossion
Jan 27, 2006·Cerebral Cortex·Adam Hampshire, Adrian M Owen
May 16, 2006·Journal of Computational Neuroscience·Aaron J GruberSara A Solla
Dec 13, 2006·Neuroscience and Biobehavioral Reviews·Robert H PietrzakPeter J Snyder
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam HampshireAdrian M Owen
Jun 18, 2008·Journal of Clinical Psychopharmacology·Timothy E Wilens
Aug 9, 2008·Neuropsychologia·Ahmed A MoustafaMichael J Frank
Dec 9, 2008·Nature·Henry GreelyMartha J Farah
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip L ClatworthyTrevor W Robbins
Sep 19, 2009·European Child & Adolescent Psychiatry·Stephen V Faraone, Jan Buitelaar
Apr 8, 2010·Current Pharmaceutical Design·Martine van SchouwenburgRoshan Cools
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernhard BaierNotger G Müller
Apr 19, 2011·Current Opinion in Neurobiology·Michael J Frank
Feb 14, 2013·Psychopharmacology·Martine R van SchouwenburgRoshan Cools
Apr 25, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marieke E van der SchaafRoshan Cools
Jun 12, 2013·Frontiers in Neuroscience·Claire Advokat, Mindy Scheithauer
Jan 16, 2014·The International Journal of Neuropsychopharmacology·A M W LinssenW J Riedel
Jan 21, 2014·Trends in Cognitive Sciences·Kartik K SreenivasanMark D'Esposito

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Citations

Apr 5, 2016·Annals of the New York Academy of Sciences·Annette B Brühl, Barbara J Sahakian
Jul 26, 2016·Frontiers in Psychiatry·Katharina BachmannAlexandra Philipsen
Nov 9, 2019·Translational Psychiatry·Arielle S KellerLeanne M Williams
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lieke HofmansRoshan Cools
Aug 11, 2020·Cerebral Cortex·Yingying Tan, Peter Hagoort
Feb 2, 2019·Psychopharmacology·Cătălina E RățalăAlan G Sanfey
Oct 3, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S LiE L Burrows
Jul 28, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Carl A RobertsCatharine Montgomery

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