Methylphenidate and environmental enrichment ameliorate the deleterious effects of prenatal stress on attention functioning

Stress : the International Journal on the Biology of Stress
Salman ZubedatAvi Avital

Abstract

Either pre- or post-natal environmental factors seem to play a key role in brain and behavioral development and to exert long-term effects. Increasing evidence suggests that exposure to prenatal stress (PS) leads to motor and learning deficits and elevated anxiety, while enriched environment (EE) shows protective effects. The dopaminergic system is also sensitive to environmental life circumstances and affects attention functioning, which serves as the preliminary gate to cognitive processes. However, the effects of methylphenidate (MPH) on the dopaminergic system and attentional functioning, in the context of these life experiences, remain unclear. Therefore, we aimed to examine the effects of EE or PS on distinct types of attention, along with possible effects of MPH exposure. We found that PS impaired selective attention as well as partial sustained attention, while EE had beneficial effects. Both EE and MPH ameliorated the deleterious effects of PS on attention functioning. Considering the possible psychostimulant effect of MPH, we examined both anxiety-like behavior as well as motor learning. We found that PS had a clear anxiogenic effect, whereas EE had an anxiolytic effect. Nevertheless, the treatment with both MPH and/o...Continue Reading

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Citations

Jul 28, 2018·Frontiers in Behavioral Neuroscience·Matthew W McDonaldDale Corbett
Sep 27, 2018·Frontiers in Behavioral Neuroscience·Jiska KentropRixt van der Veen
May 16, 2020·Frontiers in Behavioral Neuroscience·Avi AvitalDavid Coghill

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