Methylphenidate and the risk of burn injury among children with attention-deficit/hyperactivity disorder

Epidemiology and Psychiatric Sciences
Vincent Chin-Hung ChenMichael Gossop

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is associated with a higher risk of burn injury than in the normal population. Nevertheless, the influence of methylphenidate (MPH) on the risk of burn injury remains unclear. This retrospective cohort study analysed the effect of MPH on the risk of burn injury in children with ADHD. Data were from Taiwan's National Health Insurance Research Database (NHIRD). The sample comprised individuals younger than 18 years with a diagnosis of ADHD (n = 90 634) in Taiwan's NHIRD between January 1996 and December 2013. We examined the cumulative effect of MPH on burn injury risk using Cox proportional hazards models. We conducted a sensitivity analysis for immortal time bias using a time-dependent Cox model and within-patient comparisons using the self-controlled case series model. Children with ADHD taking MPH had a reduced risk of burn injury, with a cumulative duration of treatment dose-related effect, compared with those not taking MPH. Compared with children with ADHD not taking MPH, the adjusted hazard ratio for burn injury was 0.70 in children taking MPH for <90 days (95% confidence interval (CI) 0.64-0.77) and 0.43 in children taking MPH for ≥90 days (95% CI 0.40-0.47), with a 50.8% p...Continue Reading

References

Jun 1, 1997·The Australian and New Zealand Journal of Psychiatry·C H Ng
Jul 13, 2002·BMJ : British Medical Journal·Esben AgerboPreben Bo Mortensen
Mar 17, 2004·Burns : Journal of the International Society for Burn Injuries·R S MangusJ J Coleman
Apr 15, 2004·Burns : Journal of the International Society for Burn Injuries·Christopher R ThomasWalter J Meyer
Apr 21, 2004·Journal of Pediatric Psychology·Richard RoweRobert Goodman
Oct 26, 2007·Burns : Journal of the International Society for Burn Injuries·Ahmad Ghanizadeh
Aug 13, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Karen BadgerRichard J Kagan
Oct 18, 2011·Pediatrics·UNKNOWN Subcommittee on Attention-Deficit/Hyperactivity DisorderSusanna Visser
Nov 13, 2012·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·Sudha R RamanTil Stürmer
Nov 21, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lizanne J S SchwerenSarah Durston
Feb 13, 2014·Burns : Journal of the International Society for Burn Injuries·Shih-Han ChenHsu Ma
Jun 13, 2014·Developmental Medicine and Child Neurology·John Cairney
Dec 3, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mats FredriksenDawn E Peleikis
Dec 17, 2014·Pediatrics·Kenneth K C ManIan C K Wong
Sep 1, 2017·European Child & Adolescent Psychiatry·Yin-To LiaoVincent Chin-Hung Chen
Dec 16, 2017·The Journal of Clinical Psychiatry·Vincent Chin-Hung ChenMichael Gossop
May 24, 2019·Clinical Epidemiology·Cheng-Yang HsiehEdward Chia-Cheng Lai
Aug 8, 2019·JAMA Network Open·Vincent Chin-Hung ChenCharles Tzu-Chi Lee

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Citations

Feb 8, 2021·Neuroscience and Biobehavioral Reviews·Stephen V FaraoneYufeng Wang
Apr 4, 2021·International Journal of Environmental Research and Public Health·Dian-Jeng LiCheng-Fang Yen

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