Methylphenidate for alpha-interferon induced depression

Journal of Psychopharmacology
Alvaro Camacho, Bernardo Ng

Abstract

Interferon-Alpha (IFN) has been effective in the treatment of chronic viral infections and cancer albeit the added risk of severe depression. The literature has reported effectiveness in the use of antidepressants for interferon-induced depression. We report a case of severe protracted depression induced by IFN in a patient diagnosed with melanoma who responded rapidly to a course of methylphenidate using the Hamilton Depressive Rating Scale. Methylphenidate appeared to be effective in the treatment of neurovegetative symptoms of major depression induced by IFN. This report provides further clinical evidence that the neurovegetative symptoms of depression might respond better to a norepinephrine uptake inhibitor or psycho-stimulants.

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Jun 22, 2012·The International Journal of Neuropsychopharmacology·Bernardo Dell'Osso, Terence A Ketter
Jul 17, 2009·Palliative Medicine·J NiklesD Currow
Dec 7, 2011·The American Journal of Hospice & Palliative Care·Eric Prommer
Apr 22, 2008·The Cochrane Database of Systematic Reviews·M CandyM King
Nov 4, 2008·Clinical Neuropharmacology·Eitan AurielNir Giladi
Jun 23, 2012·Journal of Clinical Psychopharmacology·Sara BaraldiCarmine M Pariante

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