Methylphenidate-induced motor activity in rats: modulation by melatonin and vasopressin

Pharmacology, Biochemistry, and Behavior
Edgar Appenrodt, Helmut Schwarzberg

Abstract

Methylphenidate (MPH), a dopamine (DA) reuptake inhibitor, is well known to enhance motor activity, in part depending on the time of its application during the light-dark cycle. Moreover, after MPH administration, the hypothalamo-neurohypophysial axis including the neuropeptide vasopressin (AVP) was found influenced. Both the latter and behavioural effects of central AVP can also be modulated by the pineal gland with its light-dark-dependent activity. The present study was performed to investigate whether the pineal gland, its hormone melatonin (Mel), and AVP are involved in the MPH-evoked stimulation of activity. After application of 10 mg/kg MPH, the motor activity in pinealectomised (PE) rats was significantly higher than in sham-operated (SO) animals. After application of 250 microg Mel before MPH treatment, the stimulation of motor activity was diminished in PE rats and augmented in SO animals; however, when SO and PE rats were compared after Mel pretreatment, the reaction to MPH was nearly identical. Blocking the endogenous AVP by 25 or 1 microg of the V1a receptor antagonist d(CH(2))(5)[Tyr(Me)(2)]AVP (AAVP) before MPH treatment significantly augmented the motor activity in SO rats only and abolished the differences seen...Continue Reading

References

Jul 18, 1989·European Journal of Pharmacology·Y L Hurd, U Ungerstedt
Jan 1, 1993·Journal of Neural Transmission. General Section·N A Alexiuk, J P Vriend
Jan 1, 1993·Brain Research Bulletin·N A Alexiuk, J P Vriend
Jul 1, 1993·Pharmacology, Biochemistry, and Behavior·N R SwerdlowR L Hauger
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·M EngelmannR Landgraf
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·D A GolombekD P Cardinali
Jan 1, 1997·Life Sciences·O GaytanN Dafny
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·E AppenrodtH Schwarzberg
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·J L Roffman, L A Raskin
Jul 15, 1999·Physiology & Behavior·E Appenrodt, H Schwarzberg
May 4, 2000·Brain Research·O GaytanN Dafny
May 5, 2000·Experimental Physiology·M L Forsling
Aug 23, 2002·Behavioural Brain Research·Edgar AppenrodtHelmut Schwarzberg

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