PMID: 7370909Apr 1, 1980Paper

Methylphenidate, neuroleptics and dyskinesia-dystonia

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
A HusainP Malek-Ahmadi

Abstract

Methlyphenidate is one of two stimulant drugs used in the management of the Hyperkinetic Reaction in children. It has been known to have side effects such as dyskinesia, but this case details the emergence of dystonia and dyskinesia when the simultaneous use of methylphenidate and a phenothiazine was followed by withdrawal of the phenothiazine. It is postulated that the use of phenothiazine resulted in a post-synaptic supersensitivity which precipitated dystonia and dyskinesia when phenothiazine was withdrawn and methylphenidate reinstituted. It is also suggested that the phenothiazine dopamine-blocking action may necessitate the use of larger quantities of stimulant in order to produce the desired effect.

References

Jan 1, 1975·The American Journal of Orthopsychiatry·Michael SchleiferElena Kruger
Jan 1, 1973·The American Journal of Psychiatry·H L Klawans
Aug 3, 1972·The New England Journal of Medicine·D SaferE Barr

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Citations

Dec 1, 1994·Developmental Medicine and Child Neurology·S D MayesR E Mattison
Feb 6, 1999·Journal of Clinical Psychopharmacology·S W Stanislav, N L Childs
Jan 22, 2015·Journal of Clinical Psychopharmacology·Uğur TekinSerap Oflaz
Aug 9, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ozalp EkinciNuran Ekinci
Jan 1, 1995·International Journal of Psychiatry in Medicine·V F Holmes

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