Methylphenidate significantly improves declarative memory functioning of adults with ADHD.

Psychopharmacology
Joris C VersterBerend Olivier

Abstract

Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate. The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD. Eighteen adults with ADHD who were clinical responders to methylphenidate participated in this randomized crossover trial. After 3 days of no treatment, patients received in random order either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo, separated by a 6-7-day washout period. Patients performed an immediate word recall test 1 h after treatment administration. Three hours after intake, patients performed the second part of the memory test (delayed word recall and a recognition test). Delayed recognition and immediate recall was similar on treatment and on placebo. Delayed word recall was significantly better in the methylphenidate than in the placebo condition (F (1, 17) = 7.0, p <  0.017). A significant correlation was found between prestudy CES-D depression scores and difference scores on delayed recall (r = 0.602, p <  0.008). Methylphenidate improves declarative memory functioni...Continue Reading

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Citations

Oct 4, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Earle E BainMario D Saltarelli
Mar 14, 2013·PloS One·Anselm B M FuermaierOliver Tucha
Jul 18, 2014·Attention Deficit and Hyperactivity Disorders·Anselm B M FuermaierOliver Tucha
Apr 18, 2016·Drug and Alcohol Dependence·Michael D WunderliBoris B Quednow
Apr 19, 2016·Applied Neuropsychology. Adult·Anselm B M FuermaierOliver Tucha
Apr 8, 2020·Journal of Psychopharmacology·Patrícia Maidana MiguelLenir Orlandi Pereira
May 17, 2018·Frontiers in Aging Neuroscience·Andrew C Peterson, Chiang-Shan R Li
Dec 29, 2020·Epilepsy & Behavior : E&B·Beth A Leeman-MarkowskiKimford J Meador

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