Abstract
Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate. The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD. Eighteen adults with ADHD who were clinical responders to methylphenidate participated in this randomized crossover trial. After 3 days of no treatment, patients received in random order either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo, separated by a 6-7-day washout period. Patients performed an immediate word recall test 1 h after treatment administration. Three hours after intake, patients performed the second part of the memory test (delayed word recall and a recognition test). Delayed recognition and immediate recall was similar on treatment and on placebo. Delayed word recall was significantly better in the methylphenidate than in the placebo condition (F (1, 17) = 7.0, p < 0.017). A significant correlation was found between prestudy CES-D depression scores and difference scores on delayed recall (r = 0.602, p < 0.008). Methylphenidate improves declarative memory functioni...Continue Reading
References
May 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·L L BarrickmanE Schumacher
Jan 1, 1995·The Journal of Nervous and Mental Disease·T E WilensT J Spencer
Jun 1, 1994·Psychopharmacology·J A Camp-Bruno, R L Herting
Sep 1, 1996·The American Journal of Psychiatry·T E WilensD Geller
Jan 1, 1997·Psychological Medicine·A T BeekmanW Van Tilburg
May 1, 1997·Psychopharmacology·R ElliottT W Robbins
Jan 1, 1997·Neuropsychobiology·A UnrugG van Luijtelaar
Aug 26, 1998·Biological Psychiatry·L J SeidmanS V Faraone
Mar 24, 1999·Hippocampus·D L Schacter, A D Wagner
Apr 28, 2000·The American Journal of Psychiatry·J BiedermanS V Faraone
Jul 25, 2000·Psychiatry Research·R G RossA Radant
Dec 6, 2000·Journal of Psychopharmacology·M A MehtaB J Sahakian
Apr 22, 2003·Nature Neuroscience·Shaomin LiMichael J Rowan
Sep 1, 2004·Psychopharmacology·Danielle C TurnerBarbara J Sahakian
Mar 15, 2005·The International Journal of Neuroscience·Niels Dige, Gustav Wik
Jul 7, 2005·Psychological Medicine·J J Sandra KooijPaul P G Hodiamont
Jul 22, 2005·Journal of Integrative Neuroscience·Nicholas J CooperEvian Gordon
Sep 5, 2006·Biological Psychiatry·Alessandro BertolinoTommaso Scarabino
Sep 16, 2006·European Archives of Psychiatry and Clinical Neuroscience·A KordonK Wahl
Jan 3, 2007·European Journal of Pharmacology·Weldon E HornerHans Rollema
Mar 1, 2008·Journal of Psychopharmacology·Joris C VersterEdmund R Volkerts
Apr 22, 2008·The Cochrane Database of Systematic Reviews·M CandyM King
Jun 20, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Richard D ToddCynthia A Henderson
Citations
Oct 4, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Earle E BainMario D Saltarelli
Mar 14, 2013·PloS One·Anselm B M FuermaierOliver Tucha
Jul 18, 2014·Attention Deficit and Hyperactivity Disorders·Anselm B M FuermaierOliver Tucha
Apr 18, 2016·Drug and Alcohol Dependence·Michael D WunderliBoris B Quednow
May 6, 2016·Frontiers in Human Neuroscience·Ryan L KlineChiang-Shan R Li
Apr 19, 2016·Applied Neuropsychology. Adult·Anselm B M FuermaierOliver Tucha
May 27, 2016·CNS Drugs·Katrien De BruyckereRalf W Dittmann
Apr 8, 2020·Journal of Psychopharmacology·Patrícia Maidana MiguelLenir Orlandi Pereira
May 17, 2018·Frontiers in Aging Neuroscience·Andrew C Peterson, Chiang-Shan R Li
Jan 10, 2016·Journal of Attention Disorders·Björn BonathKerstin Krauel
Dec 29, 2020·Epilepsy & Behavior : E&B·Beth A Leeman-MarkowskiKimford J Meador