Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice

Critical Care Medicine
José Henrique P Leite-JuniorPatricia Rieken Macêdo Rocco

Abstract

Corticosteroids have been proposed to be effective in modulating the inflammatory response and pulmonary tissue remodeling in acute lung injury (ALI). We hypothesized that steroid treatment might act differently in models of pulmonary (p) or extrapulmonary (exp) ALI with similar mechanical compromise. Prospective, randomized, controlled experimental study. University research laboratory. One hundred twenty-eight BALB/c mice (20-25 g). Mice were divided into six groups. In control animals sterile saline solution was intratracheally (0.05 mL, Cp) or intraperitoneally (0.5 mL, Cexp) injected, whereas ALI animals received Escherichia coli lipopolysaccharide intratracheally (10 microg, ALIp) or intraperitoneally (125 microg, ALIexp). Six hours after lipopolysaccharide administration, ALIp and ALIexp animals were further randomized into subgroups receiving saline (0.1 mL intravenously) or methylprednisolone (2 mg/kg intravenously, Mp and Mexp, respectively). At 24 hrs, lung static elastance, resistive and viscoelastic pressures, lung morphometry, and collagen fiber content were similar in both ALI groups. KC, interleukin-6, and transforming growth factor (TGF)-beta levels in bronchoalveolar lavage fluid, as well as tumor necrosis fac...Continue Reading

References

Sep 1, 1991·The Journal of Clinical Investigation·J P Wiener-KronishM A Matthay
Sep 1, 1991·The American Review of Respiratory Disease·L S GreosM R Hill
Dec 17, 1987·The New England Journal of Medicine·G R BernardC A Metz
Jun 1, 1985·Journal of Applied Physiology·J H BatesJ Milic-Emili
Dec 1, 1995·American Journal of Surgery·W L BifflJ M Burch
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jan 1, 1996·Cell Biology International·G S Montes
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·A N ChesnuttJ G Clark
Jul 21, 1998·JAMA : the Journal of the American Medical Association·G U MeduriE A Tolley
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·C Haslett
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·N KaminskiR A Heller
Oct 6, 2000·Clinics in Chest Medicine·K P Steinberg, L D Hudson
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R P MarshallG J Laurent
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·P R RoccoW A Zin
Mar 14, 2003·The Journal of Pathology·Kar Neng LaiHui Yao Lan
Jul 5, 2003·American Journal of Respiratory and Critical Care Medicine·Patricia R M RoccoWalter A Zin
Jan 15, 2005·Journal of Applied Physiology·Sara L S MenezesPatricia R M Rocco
Jan 22, 2005·Current Opinion in Critical Care·Patricia R M Rocco, Walter A Zin
Feb 1, 2005·The Annals of Thoracic Surgery·Hyun-Sung LeeJae Ill Zo
Mar 24, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A B S FernandesP R M Rocco
Aug 20, 2005·Journal of Applied Physiology·Flavia B SantosPatricia R M Rocco
Aug 23, 2005·Proceedings of the American Thoracic Society·Robert P Schleimer
Oct 21, 2005·The New England Journal of Medicine·Turk Rhen, John A Cidlowski
Apr 21, 2006·The New England Journal of Medicine·Kenneth P SteinbergUNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network
Nov 15, 2007·Intensive Care Medicine·G Umberto MeduriDjillali Annane
Jan 16, 2008·Current Opinion in Critical Care·Patricia R M Rocco, Paolo Pelosi

❮ Previous
Next ❯

Citations

Aug 30, 2008·Critical Care Medicine·Carl Roosens, Jan Poelaert
Jun 16, 2010·Critical Care : the Official Journal of the Critical Care Forum·Pedro L SilvaPatricia R M Rocco
Feb 11, 2016·Nutrients·Gisele P OliveiraPatricia R M Rocco
Jul 12, 2011·Critical Care Clinics·Paul E MarikDjillali Annane
Aug 17, 2010·Respiratory Physiology & Neurobiology·Mônica C M ChaoPatricia R M Rocco
Oct 13, 2009·Respiratory Physiology & Neurobiology·Andréia F RzezinskiPatricia R M Rocco
Aug 2, 2011·Respiratory Physiology & Neurobiology·Raquel S SantosPatricia R M Rocco
Sep 2, 2009·Memórias do Instituto Oswaldo Cruz·André M JapiassúHugo C Castro-Faria-Neto
Jun 15, 2017·Archives of Pathology & Laboratory Medicine·Vera Luiza CapelozziMaxwell Lawrence Smith
Jun 22, 2010·Critical Care Medicine·Indianara M AraújoPatricia R M Rocco
Dec 12, 2018·Current Opinion in Critical Care·Pratik Sinha, Carolyn S Calfee
Dec 17, 2009·Medicine and Science in Sports and Exercise·Daniel Souza RamosRodolfo de Paula Vieira
Apr 22, 2010·Expert Review of Respiratory Medicine·G Umberto MeduriScott E Sinclair
Sep 2, 2010·Critical Care : the Official Journal of the Critical Care Forum·Andrew W KirkpatrickKevin B Laupland
Nov 15, 2019·Physiological Reports·Mélissa Aubin VegaEmmanuelle Brochiero
Mar 3, 2020·Frontiers in Physiology·Hannes DomscheitPeter M Spieth
Mar 25, 2020·Critical Care : the Official Journal of the Critical Care Forum·Jennifer G Wilson, Carolyn S Calfee
Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Barbara DraslerBarbara Rothen-Rutishauser
Jan 20, 2021·Physiological Research·D Mokrá
Oct 26, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Sabrina Setembre BatahAlexandre Todorovic Fabro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Patricia Rieken Macêdo RoccoWalter Araujo Zin
Journal of Applied Physiology
Sara L S MenezesPatricia Rieken Macêdo Rocco
Journal of Applied Physiology
Flavia B SantosPatricia Rieken Macêdo Rocco
Shock
William J HubbardIrshad H Chaudry
© 2022 Meta ULC. All rights reserved