PMID: 9194690Jan 1, 1997Paper

Methylprednisolone inhibits neutrophil-endothelial cell interactions induced by interleukin-1beta under flow conditions

Life Sciences
N YoshidaM Kondo

Abstract

The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system. Human neutrophilic polymorphonuclear leukocytes (PMN) were perfused at a shear stress of 1 dyne/cm2 on human umbilical vein endothelial cells (HUVEC) pretreated with IL-1beta (20 U/mL) for 4 hours. Many PMN adhered to IL-1-stimulated HUVEC and then migrated beneath endothelial cell monolayers. Treatment of HUVEC with m-PSL inhibited adherence and migration of PMN in a dose dependent manner. M-PSL also inhibited IL-1beta-induced upregulation of E-selectin and ICAM-1 on HUVEC in a dose dependent manner. These results suggest that m-PSL works as an anti-inflammatory agent through inhibiting PMN-endothelial cell interactions.

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Citations

Feb 21, 2004·International Immunopharmacology·Gaku MitsuiMasatoshi Kato
Apr 8, 2006·Respiratory Research·Bhupinder S Mann, Kian Fan Chung
Jun 6, 2013·International Journal of Nanomedicine·Blanca Tobar-GrandeCarolina Gómez-Gaete
Mar 11, 2000·The Journal of Laboratory and Clinical Medicine·B JilmaO F Wagner
Jul 27, 2005·Multiple Sclerosis : Clinical and Laboratory Research·J S Sloka, M Stefanelli
May 19, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·N A PatelS L Chang

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