PMID: 7009652Apr 1, 1981Paper

Methylprednisolone prevention of increased lung vascular permeability following endotoxemia in sheep

The Journal of Clinical Investigation
K L BrighamC R McKeen

Abstract

To see whether methylprednisolone would affect the pulmonary vascular response to endotoxemia, we studied responses to endotoxemia in the presence and absence of methylprednisolone in the same chronically instrumented, unanesthetized sheep. Infusion of Escherichia coli endotoxin (0.70-1.33 mug/kg) caused an initial period of marked pulmonary hypertension followed several hours later by a long period of increased vascular permeability when pulmonary vascular pressures were near base line (base-line pulmonary artery pressure (PPa) = 21+/-1 cm H(2)O SE, left atrial pressure (Pla) = 1+/-3; experimental PPa = 20+/-3, Pla = 3+/-4; P = NS), lung lymph flow ( Qlym) was high (base-line Qlym = 7.2+/-0.2 ml/h; experimental Qlym = 23.2+/-1.0; P < 0.05) and lymph/plasma protein concentration (L/P) was high (base-line L/P = 0.65+/-0.04; experimental L/P = 0.79+/-0.05; P < 0.05). When methylprednisolone (1.0 g + 0.5 g/h i.v.) was begun 30 min before the same dose of endotoxin was infused, the initial pulmonary hypertension was less and the late phase increase in lung vascular permeability was prevented (experimental PPa = 24+/-1, Pla = 1+/-1, Qlym = 10.0+/-0.4; L/P = 0.56+/-0.03). Qlym and L/P were significantly (P < 0.05) lower than with end...Continue Reading

References

Aug 1, 1979·Circulation Research·K L BrighamJ Haynes
May 1, 1978·The Journal of Clinical Investigation·C R McKeenT R Harris
Sep 1, 1976·Annals of Surgery·W Schumer
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S L Hong, L Levine
Nov 11, 1975·The Journal of Surgical Research·N C StaubW C Woolverton
Oct 1, 1974·The Journal of Clinical Investigation·K L BrighamN C Staub
May 1, 1980·Prostaglandins·B Samuelsson, S Hammarström
May 1, 1980·Prostaglandins·T J Williams, P J Piper

❮ Previous
Next ❯

Citations

Aug 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S ShioyaH Yamabayashi
Apr 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S ShioyaK C Goodrich
Jan 1, 1984·Intensive Care Medicine·W J Sibbald
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers
Sep 1, 1986·The Proceedings of the Nutrition Society·L A Boxer
Nov 16, 2004·Critical Care Medicine·Didier Keh, Charles L Sprung
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·S WaltherS Lennquist
Jan 1, 1991·Acta Anaesthesiologica Scandinavica. Supplementum·A Jolin, L Bjertnaes
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·K KawabataH Ohno
Feb 1, 1990·The American Review of Respiratory Disease·Y Sibille, H Y Reynolds
Oct 1, 1990·The American Review of Respiratory Disease·E H JeromeN C Staub
Jul 5, 2003·American Journal of Respiratory and Critical Care Medicine·Patricia R M RoccoWalter A Zin
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Jean-Louis Vincent, Edward Abraham
Sep 1, 1983·The Journal of Clinical Investigation·R WinnJ Hildebrandt
Nov 1, 1984·The Journal of Clinical Investigation·J R SnapperK L Brigham
Feb 7, 2001·Pediatric Research·R HolopainenP Kääpä
Mar 1, 1990·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·A DwengerH Tscherne
Jan 1, 1983·Intensive Care Medicine·J H Newman
Jul 1, 1995·Experimental Lung Research·S SyrbuH M Smilowitz
Mar 3, 2011·Chest·Jason N KatzRichard C Becker
Nov 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J J TseJ S Topf
Jul 13, 1984·The American Journal of Medicine·R C Bone, E R Jacobs
Feb 1, 1989·Toxicology and Applied Pharmacology·M Vassilyadi, R P Michel
Jul 1, 1985·The Journal of Surgical Research·G J SlotmanD S Gann
Mar 1, 1991·The Journal of Surgical Research·A MatsumuraY Kawashima
Mar 1, 1987·The Journal of Surgical Research·T M FuhrmanP V Halushka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.