Methylselenocysteine preventing castration-resistant progression of prostate cancer

The Prostate
Yanbo LiuYan Dong

Abstract

Castration-resistant progression of prostate cancer after androgen deprivation therapy remains a critical challenge in the clinical management of prostate cancer. Resurgent androgen receptor activity is an established driver of castration-resistant progression, and upregulation of androgen receptor expression has been implicated to contribute to the resurgent androgen receptor activity. We reported previously that methylselenocysteine can decrease the expression and activity of androgen receptor. Here we investigated the ability of methylselenocysteine to inhibit castration-resistant progression of prostate cancer. The regrowth of LNCaP prostate cancer xenografts after castration was monitored. The levels of prostate-specific antigen in mouse serum were measured by ELISA. Tumor cell proliferation and apoptosis were analyzed via Ki-67 immunohistochemistry and TUNEL assay, respectively. Intratumoral angiogenesis was assessed by immunohistochemistry staining of vascular endothelial growth factor and CD31. We showed that methylselenocysteine delayed castration-resistant regrowth of LNCaP xenograft tumors after androgen deprivation. This was accompanied by decreased serum levels of prostate-specific antigen, inhibition of prostate c...Continue Reading

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Citations

Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nuria Díaz-ArgelichCarmen Sanmartín
Mar 25, 2019·Journal of Cellular and Molecular Medicine·Hongyan XiaYan Dong
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha

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