Methylsulfonylated Polyketides Produced by Neosartorya udagawae HDN13-313 via Exogenous Addition of Small Molecules

Journal of Natural Products
Guihong YuDehai Li

Abstract

Two new polyketides modified with a rare methylsulfonyl group, 3-methoxy-6-methyl-5-(methylsulfonyl)benzene-1,2,4-triol (1) and neosartoryone A (2), along with a biogenetically related compound (3), were isolated from Neosartorya udagawae HDN13-313 cultivated with the DNA methyltransferase inhibitor 5-azacytidine. The methylsulfonyl group of 1 and 2 was proven to be derived from DMSO, which was used as the solvent to dissolve 5-azacytidine. This is the first report of a fungus that can achieve a sulfonylation-like modification of natural products utilizing DMSO as a sulfur source. Compound 2 showed lipid-lowering activity in vitro comparable to simvastatin.

References

Nov 7, 2008·Journal of Natural Products·Lin DuQianqun Gu
Jul 11, 2009·Organic & Biomolecular Chemistry·Kirstin Scherlach, Christian Hertweck
Jan 10, 2012·Natural Product Reports·James F SanchezClay C C Wang
Sep 16, 2015·Current Topics in Medicinal Chemistry·Minghao FengXuefeng Jiang
Apr 5, 2017·Chemical Reviews·Abraham J WaldmanEmily P Balskus

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Citations

Jul 28, 2019·Marine Drugs·Meng BaiCai-Juan Zheng
Feb 12, 2021·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Feb 25, 2021·Organic & Biomolecular Chemistry·Wei ZhouXiong-Li Liu

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